Significance of Serotonin receptor
Serotonin receptors are proteins that interact with serotonin, a neurotransmitter involved in mood regulation and various neurological processes. These receptors are found in the brain and body, mediating the effects of serotonin on mood, cognition, and other functions. They are targeted by drugs like SSRIs, ergot alkaloids, and certain antipsychotics, and play roles in conditions like migraine, bladder relaxation, and major depressive disorder.
Synonyms: 5-hydroxytryptamine receptor, 5-ht receptor
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Serotonin receptor in scientific sources
Serotonin receptors are targets for various drugs and neurotransmitters, mediating serotonin's effects in the brain and body. They influence mood, cognition, and various physiological processes. Their role extends to conditions like depression, migraine, and potentially Parkinson's disease, while also being involved in the action of certain medications.
From: International Journal of Pharmacology
(1) To investigate whether these receptors participate in the antinociceptive activity found for Calein D, rats were pretreated with methiothepin.[1] (2) Serotonin receptors, also known as 5-HT receptors, are influenced by PCP, which can elevate brain extracellular serotonin levels by interacting with the serotonin reuptake site.[2] (3) The study aims to help researchers identify constituents in Macrotyloma uniflorum that interact with serotonin receptors, relevant to depression therapy.[3] (4) Serotonin receptors are involved in the action of ergot alkaloids, contributing to their antimigraine effects.[4] (5) Ginger's hypoglycaemic action may involve interactions with serotonin receptors, potentially contributing to its blood glucose-lowering effects.[5]
From: Asian Journal of Pharmaceutics
(1) Agomelatine functions as an antagonist at these receptors, targeting the relevant receptors in antidepressant therapy.[6] (2) A receptor that interacts with agomelatine, contributing to its antidepressant effects.[7] (3) The antipsychotic activity of AM is thought to be due to antagonistic activity on 5-HT 2 A serotonin receptors.[8]
From: South African Family Practice
(1) Olanzapine and quetiapine antagonise these receptors while stimulating 5 HT 1 A receptors, which is thought to contribute to their antidepressant effects.[9] (2) Sumatriptan has a high specificity for the 5-HT 1 B and 5-HT 1 D receptors, which are also known as these.[10]
From: The Malaysian Journal of Medical Sciences
(1) Serotonin receptors are the receptors that bind to serotonin, a neurotransmitter involved in multiple functions in the central nervous system, and there are several types.[11]
From: International Journal of Pharmacology
(1) 5-hydroxytryptamine acts on serotonin receptors to cause vasoconstriction.[12] (2) Receptors in the brain that bind to serotonin, and which are a primary target for selective serotonin reuptake inhibitors (SSRIs) like escitalopram.[13] (3) Serotonin receptors, particularly 5-HT7 and 5-HT3, have been demonstrated to mediate bladder relaxation, and their interaction with venlafaxine was studied.[14] (4) Serotonin receptors were not found to play a role in the inhibitory effects of Aridanin on NIR, locomotor activity, and Y-Maze.[15] (5) Serotonin receptors are targeted by certain drugs, including belaadrenergic blocking agents, for their potential effects on the brain and migraine.[16]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Serotonin receptor 5B (5-HT5B) gene expressions were significantly decreased in the arsenic-exposed group compared to control group, suggesting that developmental arsenic exposure might affect social behavior by modulating serotonin receptors.[17] (2) These receptors and the pathways they are involved in help produce therapeutic effects and side effects.[18] (3) The serotonin receptor is a component in understanding body functions, especially in the regulation of brain processes like motivation, learning, and memory.[19] (4) The activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors has been studied.[20]
From: South African Journal of Psychiatry
(1) Second-generation antipsychotics have a high affinity for these receptors.[21] (2) These are specific sites in the brain that bind to serotonin, a neurotransmitter involved in mood regulation and other functions.[22]