Significance of Robustness
Robustness refers to the ability of an analytical method to remain unaffected by small variations in method parameters, ensuring consistency and reliability during analysis. This includes resistance to minor changes in conditions such as flow rate, temperature, or solvent composition. Robustness is crucial for confirming the reliability and stability of analytical methods across different experimental situations. It is assessed during method validation, highlighting the method's dependable performance despite small, deliberate variations in its parameters.
Synonyms: Durability, Strength, Resilience, Reliability, Dependability
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The concept of Robustness in scientific sources
Robustness measures an analytical method's reliability and consistency by demonstrating its resilience to minor, unintentional or intentional variations in method parameters, ensuring dependable outcomes under varying conditions.
From: Asian Journal of Pharmaceutics
(1) This is evaluated by making small changes to flow rate, mobile phase, and temperature.[1] (2) A validation parameter assessed by making small, deliberate changes to method parameters (e.g., flow rate, pH) to evaluate the method's reliability.[2] (3) This refers to the study of the method's ability to remain unaffected by small changes in the method's optimized parameters.[3]
From: Religions Journal (MDPI)
(1) A complex structure of integration enhanced its robustness and gave it the ability to endure potential disruptions.[4]