Significance of Renal impairment
Renal impairment refers to reduced kidney function, which can significantly impact drug dosing and safety profiles for various medications in patients with chronic diseases. This condition affects how well the kidneys filter waste products from the blood, influencing treatment options and medication metabolism. It is particularly crucial for determining patient eligibility in clinical studies and managing medications like tolvaptan, metformin, and others, as impaired kidney function may lead to complications and adverse drug reactions.
Synonyms: Kidney dysfunction, Renal failure, Kidney impairment, Renal insufficiency, Nephropathy, Kidney injury, Kidney disease, Renal damage
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Renal impairment in scientific sources
Renal impairment involves reduced kidney function, impacting the safe dosing of medications like tolvaptan in chronic kidney disease and heightening hypoglycemia risk in patients on gliclazide. Both conditions necessitate careful patient management.
From: The Malaysian Journal of Medical Sciences
(1) Patients with mild hydronephrosis without this condition or any associated complication can be managed conservatively with periodic examinations.[1] (2) This is a potential complication that may occur in patients with typhoid fever, potentially affecting the kidneys and their ability to function correctly.[2] (3) This refers to a problem with the kidneys, which would exclude a patient from the study.[3] (4) This is a condition where the kidneys are not functioning properly, and it is one of the comorbidities considered in the study.[4] (5) Renal impairment was suggested by the study, as the serum creatinine level during the event indicated possible poor renal function, potentially affecting drug clearance.[5]