Significance of Reactive oxygen species
Reactive oxygen species (ROS) are unstable, harmful molecules containing oxygen that can damage cells, DNA, and proteins, leading to oxidative stress and contributing to various diseases. They are byproducts of normal metabolic processes and can be generated in excess under certain conditions. Antioxidants play a crucial role in neutralizing ROS and preventing cellular damage.
Synonyms: Oxidative species, Reactive radicals, Oxygen radicals, Oxygen-derived species, Reactive species
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Reactive oxygen species'
In Hinduism, Reactive Oxygen Species (ROS) represent unstable, harmful molecules that damage cells and contribute to disease. Antioxidants are seen as essential for neutralizing ROS, protecting biomolecules, and maintaining cellular health, reflecting a focus on balance and well-being.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Reactive oxygen species (ROS), which cause oxidative damage, are susceptible to harm from antioxidants.[1] (2) The phytoconstituents mainly act to enhance the level of antioxidation within the body and clear these in cancerous cells.[2] (3) These are molecules that are generated and scavenged by certain enzymes in the brain, as indicated by the provided text.[3] (4) These are a type of free radical that can cause destructive and lethal cellular effects, such as oxidizing membrane lipids, cellular proteins, DNA, and enzymes, thus shutting down cellular respiration.[4] (5) Cells under aerobic conditions are always threatened with the insult of Reactive Oxygen Species, which however are efficiently taken care off by the highly powerful antioxidant systems of the cell.[5]
From: International Research Journal of Ayurveda and Yoga
(1) Yoga aims at reducing the toxic buildup of these elements and consequent damage from oxidative stress.[6] (2) These cause hepatocyte injury and promote lipotoxicity.[7] (3) Triphala’s rich polyphenol and flavonoid content scavenges these species, reducing oxidative stress.[8] (4) Internal damage brought on by reactive oxygen species is known as oxidative stress, and it may then lead to aging and the development of heart disease, cancer, arthritis, and other conditions.[9] (5) Antioxidants neutralize these harmful molecules, making them pivotal for maintaining good health.[10]
From: Journal of Ayurvedic and Herbal Medicine
(1) These are highly reactive and can damage DNA, Proteins and Lipids, with the accumulation in hepatic cells leading to the oxidation of Glutathione and ultimately hepatic damage, causing oxidative stress and liver injury.[11] (2) Highly reactive molecules, often referred to as free radicals, that can cause cellular damage and contribute to various health issues, emphasizing the role of antioxidants in their neutralization.[12] (3) These are dangerous molecules that cause cellular damage, and antioxidants are utilized to prevent this damage, and this was a focus of the study.[13] (4) These are unstable molecules that can cause harm, and are involved in the development of various diseases and health issues.[14] (5) These are produced and can help in the progression of the disease.[15]
The concept of Reactive oxygen species in scientific sources
Reactive oxygen species (ROS) are unstable, chemically reactive molecules containing oxygen, produced during metabolic processes and oxidative stress. They damage cells, nucleic acids, proteins, and lipids, contributing to diseases like cancer, diabetes, and Alzheimer's, while also impacting wound healing and pregnancy outcomes.
From: International Journal of Pharmacology
(1) Occlusion of a renal artery caused a systemic increase in these (ROS), which further contributed to elevated oxidative stress.[16] (2) Oxidative stress is the imbalance between the amount of these and enzymatic and nonenzymatic antioxidants.[17] (3) The Nrf2/ARE pathway eliminates these species in cells and suppresses oxidative stress.[18] (4) Also known as ROS, it occurs by the presence of free radical production and antioxidant capacity imbalance.[19] (5) They can have Polyunsaturated Fatty Acids inside the membranes to be damaged, leading to the development of peroxyl radicals.[20]
From: Asian Journal of Pharmaceutics
(1) Smoking can likewise bring about the presentation of ROS and leukocytes in the sperm, increasing the potential for damage.[21] (2) The enzyme CAT plays a significant role in the protection of cells from any oxidative damage produced by these.[22] (3) The decrease in weight of testis, prostate, seminal vesicle and epididymis may be either due to decrease in concentration of T, FSH, and LH or increase in the formation of reactive oxygen species.[23] (4) Flavonoids can inhibit oxidases such as lipoxygenase, cyclooxygenase, and xanthine oxidase, thus prevent in vivo development of reactive oxygen species.[24] (5) Alloxan was responsible for the production of these, which causes the destruction of pancreatic ß-cells and produced hyperglycemia.[25]
From: The Malaysian Journal of Medical Sciences
(1) These are molecules that can cause damage, and the phototoxic effect of the reactive oxygen species produced by a light microscope’s operation can cause the devitalisation of conjunctival and corneal epithelial cells, squamous metaplasia of the conjunctival epithelium and a decrease in conjunctival goblet cell density.[26] (2) These are products of oxidative stress, and they are primary initiators in the cascade of events contributing to oral mucositis, and they can directly damage cells, tissues, and blood vessels, and they also affect other tissues.[27] (3) These are molecules that can exacerbate neurotoxicity in Alzheimer's disease due to an accelerated generation and decline in antioxidant defense.[28] (4) The increase in the production of reactive oxygen species and oxidative stress destroy β-cells in pancreatic tissue and thus play an important role in diabetes.[29] (5) Reactive oxygen species are produced during strenuous exercise and can lead to oxidative stress and cellular damage.[30]
From: Journal of Medicinal Plants for Economic Development
(1) These are molecules that can be destructive to lipids, proteins, and nucleic acids, and can lead to increased membrane permeability.[31] (2) When H 2 O 2 enters the hepatocytes, it can produce reactive oxygen species (ROS), which are highly reactive oxygen-containing molecules, which can harm hepatocellular components.[32] (3) These are molecules that can damage cells, and antioxidants help to neutralize these molecules.[33] (4) These are unstable molecules that can cause damage to cells and contribute to oxidative stress, a concept explored within the text.[34] (5) Reactive oxygen species are unstable molecules that can cause damage within cells, and their excessive production is linked to poor semen parameters and male infertility.[35]
From: Onderstepoort Journal of Veterinary Research
(1) These are generated during the metabolism of aflatoxin B1 and can lead to cell damage.[36] (2) These are molecules that can damage cells, and the study examines how a bacterial enzyme can help in managing their effects.[37] (3) The mechanism of action of AA in reducing heat stress may also be through the detoxification of reactive oxygen species known to be in abundance in the body during stressful conditions.[38]
From: Journal of Public Health in Africa
(1) These are molecules that are produced as a result of normal cellular metabolism, and their overproduction can lead to oxidative stress, potentially causing cell injury and apoptosis.[39] (2) Highly oxidizing molecules that can be reduced by the consumption of rooibos tea, potentially preventing or treating chronic illnesses, as described.[40] (3) These species can cause serious damage to DNA, proteins, and lipids, and are involved in endothelial damage by ox-LDL, as well as interfering with redox balance.[41]
From: South African Family Practice
(1) These are collective labels for the known substances most often produced by the body or from external sources, and can be thought of as 'prooxidants' within the body.[42] (2) The uptake of aminoglycosides leads to an increased formation of these, which can cause cell damage if not neutralized.[43]
From: South African Journal of HIV Medicine
(1) Reactive oxygen species, such as superoxide, are formed when oxygen is reduced and have been associated with the progression of cardiovascular disorders in the study.[44]
From: International Journal of Pharmacology
(1) Unstable molecules that can cause cellular damage, their levels increase in obesity and decline with weight loss, and green tea exhibits antioxidant properties against them.[45] (2) Highly reactive molecules generated during intracellular metabolism that can damage lipids, proteins, and DNA when overproduced.[46] (3) Reactive oxygen species are correlated with the levels of inflammatory cytokines and 25-hydroxy vitamin D in rheumatoid arthritis patients.[47] (4) Harmful substances generated by certain medications like cyclophosphamide, contributing to tissue damage and oxidative stress.[48] (5) Reactive Oxygen Species (ROS) contribute to increased oxidative stress, a fundamental mechanism in diabetic complications, leading to nerve damage.[49]
From: International Journal of Pharmacology
(1) These cause cellular proteins and lipids to be damaged in the lens, and can cause soluble proteins to precipitate, mainly responsible for light refraction.[50]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Benzene metabolism involves redox cycling producing this, leading to reduced gluthathione and causing further oxidative stress in bone marrow cells.[51]
From: South African Journal of Psychiatry
(1) These are molecules that were found to be accumulated by zinc, and were part of the conclusion that zinc toxicity involved the generation of reactive oxygen species and the activation of the MAP-kinase pathway.[52]