Significance of Quantitation limit
The Quantitation limit (QL) is defined as the lowest concentration of an analyte that can be quantitatively determined with acceptable precision and accuracy. It is established at 3.5µg/ml for Dolasetron, highlighting its role in quantitative assays. This limit is crucial for measuring low levels of compounds, particularly in assessing impurities and degradation products, ensuring reliable detection and measurement in analytical procedures across various substances.
Synonyms: Detection limit, Quantification limit, Limit of quantification, Analytical sensitivity
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The concept of Quantitation limit in scientific sources
Quantitation limit is the minimum concentration of an analyte that can be accurately and reliably measured using a specific analytical method, ensuring suitable precision and accuracy in the results obtained.
(1) The lowest concentration of an analyte that can be quantified with acceptable precision and accuracy in an analytical procedure.[1] (2) The theoretical minimum concentration of digoxin that can be reliably detected using the validated spectrophotometric method, specified as 0.008 µg mL-1.[2] (3) A parameter of quantitative assays for low levels of compounds in sample matrices, used particularly for determining impurities and/or degradation products.[3] (4) The smallest concentration of an analyte that can be quantitatively determined with suitable accuracy and precision.[4] (5) The lowest concentration of an analyte that can be quantitatively determined with acceptable precision and accuracy.[5]