Significance of Proof of concept
Proof of concept studies involve preliminary demonstrations of feasibility and potential efficacy. These studies assess treatment ideas, concepts, or technologies in a limited context. Examples include evaluating drug formulations, quality improvement interventions, and alternative information systems. Proof of concept studies aim to show that an approach has promise before larger, more comprehensive trials are conducted. They provide early-phase evidence that a treatment or method warrants further investigation.
Synonyms: Demonstration, Prototype, Validation, Feasibility study, Pilot project, Test case, Model, Trial, Example, Specimen, Experiment, Pilot, Mock-up
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Proof of concept in scientific sources
Proof of concept demonstrates treatment feasibility and potential efficacy through preliminary studies. It assesses initial effectiveness before larger trials, validating concepts in specific contexts and showing potential for new technologies.
From: Sustainability Journal (MDPI)
(1) Proof of concept refers to evidence or demonstration that a design concept or theory is feasible, and proof of concept often involves preliminary studies.[1] (2) Develop and validate prototypes or pilot projects to demonstrate the feasibility of nanotech through proof of concept and pilots in industrial applications.[2] (3) The proof-of-concept is a case study that uses a machine learning model as a Waste Management 4.0 application, which helps to explore the current applications of WM 4.0.[3] (4) Citizen-science informed intermediaries might create and disseminate tangible proof of alignments and make them visible with case-studies, proof of concept, and reproducibility when working with energy communities.[4] (5) It is a demonstration to verify that certain concepts or theories have the potential for practical application, often abbreviated as PoC, validating the feasibility of a system.[5]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Having successfully implemented the "proof of concept" for stock management within OR suite 6, this has now been rolled out to the other seven ORs.[6] (2) The study is a proof of concept that reveals differences among individuals based on the severity of their infection, including those not infected and those infected with other HCoVs.[7] (3) A proof of concept is the obtainment of 2.0 ± 0.23 mg/L of carotenoids starting from 9% (w/v) of initial biomass with a yield of 0.0053 ± 0.0006% on total sugars provided.[8] (4) The study serves to demonstrate proof-of-concept, indicating that the intervention has the potential to be effective and warrants further investigation in a larger study.[9] (5) The text identifies the study as a proof of concept, indicating that it is not a national-level study due to the small sample size, thus suggesting a need for further research.[10]
From: South African Family Practice
(1) This is a type of study used to assess the initial feasibility and effectiveness of a treatment, like bromocriptine, before a larger trial is undertaken.[11] (2) This study aimed to evaluate a method to test the concept, or idea, of a quality improvement intervention to strengthen well-child service provision and integration with maternal health services in five rural clinics.[12] (3) This study was a proof of concept, showing that tablet computers are a feasible alternative to paper-based information systems for nurses at CHCs.[13]
From: African Journal of Primary Health Care and Family Medicine
(1) These are demonstrations of a technology or approach, often within a small context, that show its potential but may lack the sustainability needed for widespread use.[14]
From: International Journal of Pharmacology
(1) The HERACLES trial served as a proof-of-concept for using dual-targeted therapy with trastuzumab and lapatinib in a specific cancer context.[15]
From: Asian Journal of Pharmaceutics
(1) It is also known as Phase 2 a, and the exposure would have been adequate for the NCE to provide the right signals.[16]
From: South African Journal of Physiotherapy
(1) To the researchers' knowledge, this is the first review that focuses on a proof of concept for Community-Based Rehabilitation in Southern Africa, aiming to assess the feasibility and viability of CBR in the region.[17]