Significance of Proinflammatory cytokine
Proinflammatory cytokines are signaling molecules produced primarily by immune cells that promote inflammation. They are involved in various pathological conditions, including periodontal disease, liver damage during acetaminophen overdose, and chronic inflammatory diseases such as arthritis. Cytokines like IL-6, TNF-α, and IL-1β are crucial in the immune response to infections and tissue injury, often leading to complications when released in excess. Their role is significant in both acute and chronic inflammation, impacting health outcomes.
Synonyms: Inflammatory cytokine, Proinflammatory mediator, Pro-inflammatory cytokine, Inflammatory mediator, Pro-inflammatory mediator
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The concept of Proinflammatory cytokine in scientific sources
Proinflammatory cytokines are chemical messengers that promote inflammation and play a crucial role in autoimmune responses and the immune system, often increasing during oxidative stress and tissue injury, exemplified by molecules like TNF-α.
(1) Proinflammatory cytokines are substances that promote inflammation, and the text explores their role in relation to febrile temperatures.[1] (2) Proinflammatory cytokines, such as IFN-γ and IL-2, are produced by Th1 cells, which participate effectively in CMI.[2] (3) Proinflammatory cytokines are activated by an accumulation of ROS and RNS from NOX and environmental stressors, leading to inflammation and epidermal hyperproliferation, and they are increased in psoriasis.[3] (4) These are specific proteins that are involved in the inflammatory response and can contribute to various pregnancy complications, including preterm PROM.[4] (5) These are signaling molecules released by immune cells to promote inflammation, and can be released by macrophages in response to certain toxins.[5]