Significance of Pregnane X receptor
The Pregnane X receptor, according to Science, regulates enzymes in cholesterol metabolism and Cytochrome P450 3A23 expression, which could mediate how drugs affect cholesterol. Health Sciences defines the Pregnane X receptor as a nuclear receptor that sesamin inhibits. This inhibition has potential implications for drug metabolism. Thus, the Pregnane X receptor plays a role in both cholesterol and drug metabolism.
Synonyms: Pxr, Steroid receptor, Nuclear receptor, Transcription factor
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The concept of Pregnane X receptor in scientific sources
Pregnane X receptor is a nuclear receptor. Sesamin inhibits it, impacting drug metabolism. It also regulates cholesterol metabolism enzymes and Cytochrome P450 3A23, potentially influencing drug effects on cholesterol.
From: International Journal of Pharmacology
(1) A receptor that regulates enzymes involved in cholesterol metabolism and Cytochrome P450 3A23 expression, potentially mediating drug effects on cholesterol.[1]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Pregnane X receptor agonistic activity is studied in 200 pesticides using in vitro reporter gene assays, comparing human and mouse responses.[2]