Significance of Platelet-rich-fibrin
Platelet-rich fibrin (PRF) is a second-generation platelet concentrate derived from a patient's blood, known for its healing properties. This autologous material contains a high concentration of platelets, leukocytes, and growth factors, promoting tissue regeneration and enhancing healing in various surgical procedures, particularly in dentistry and periodontal treatment. PRF serves as a scaffold to support wound healing, accelerate tissue repair, and reduce postoperative pain while being easy to prepare without the need for anticoagulants.
Synonyms: Fibrin matrix, Platelet-rich plasma, Autologous platelet concentrate
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The concept of Platelet-rich-fibrin in scientific sources
Platelet-rich fibrin is a platelet concentrate in plasma that enhances healing in periodontal treatment by naturally polymerizing and releasing growth factors, which support cell recruitment and stimulate tissue regeneration.
From: The Malaysian Journal of Medical Sciences
(1) A second-generation platelet concentrate that is simpler to prepare than platelet-rich plasma and does not require biochemical processing.[1]
From: South African Family Practice
(1) This is a matrix that serves as a scaffold for the platelets to enable sustained growth factor release, which is a result of the combination of calcium chloride and PRP.[2]