Significance of Physical modification
Physical modification encompasses various techniques that alter the physical characteristics of materials, such as native starch and pharmaceuticals, without chemical treatments. This includes blending with plasticizers to enhance mechanical strength, as well as strategies for improving drug delivery systems through changes in size or dispersion to boost solubility and dissolution rates. Overall, physical modification is essential for optimizing the properties of drugs and other materials, thereby enhancing their effectiveness and usability.
Synonyms: Alteration, Adjustment, Modification, Transformation, Change, Adaptation, Manipulation, Customization, Enhancement, Improvement
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The concept of Physical modification in scientific sources
Physical modification involves altering a material's physical properties through methods like blending, enhancing drug dissolution, or changing starch characteristics to improve traits such as mechanical strength, solubility, and granule structure.
From: World Journal of Pharmaceutical Research
(1) Techniques used to change the physical properties of polysaccharides without altering their chemical structure.[1] (2) Techniques such as particle size reduction or micronization used to enhance drug solubility.[2] (3) Strategies employed to alter the physical properties of a drug, potentially impacting its solubility and dissolution rates, contributing to improved drug delivery systems.[3] (4) Physical modification refers to changes made to a material's physical properties, including blending with plasticizers or other polymers, to improve desired characteristics like mechanical strength.[4] (5) Changes to the physical properties of a drug to enhance its dissolution and solubility characteristics.[5]