Significance of Phosphodiesterase
Phosphodiesterase, an enzyme, is highlighted in both Science and Health Sciences. Science indicates that inhibiting phosphodiesterase, particularly PDE4, can impact inflammatory diseases. Additionally, it describes phosphodiesterase as an enzyme that breaks down cyclic nucleotides and mediates antispasmodic and bronchodilator activities. Health Sciences identifies phosphodiesterase as an enzyme family regulating cellular concentrations of cyclic nucleotides. It also mentions that phosphodiesterase is crucial in therapeutics and that its inhibition can lead to smooth muscle relaxation.
Synonyms: Pde, Phosphodiesterases,
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Phosphodiesterase in scientific sources
Phosphodiesterase (PDE) is an enzyme family regulating cyclic nucleotides like cAMP and cGMP. Inhibiting PDEs, such as with theophylline, sildenafil, or Kreysigine, can lead to smooth muscle relaxation and various pharmacological effects. PDEs are crucial in therapeutics and inflammatory disease.
From: International Journal of Pharmacology
(1) These are a superfamily of enzymes which catalyze the hydrolysis of the cyclic nucleotides, like cAMP and cGMP, into inactive counterparts.[1] (2) Phosphodiesterases are a class of enzymes found in most tissues that regulate cyclic adenosine monophosphate and cyclic guanosine monophosphate, which are involved in numerous physiological functions.[2] (3) Phosphodiesterase is an enzyme that controls cellular levels of cyclic nucleotides, and its inhibition by compounds like theophylline and potentially Kreysigine leads to smooth muscle relaxation.[3] (4) Phosphodiesterases are enzymes that are important in the development of therapeutics, representing a journey towards new treatments.[4] (5) An enzyme family that breaks down cyclic nucleotides like cyclic GMP, thereby regulating their cellular concentrations and downstream effects.[5]
From: Asian Journal of Pharmaceutics
(1) Papaverine's ability to inhibit this contributes to its relaxant action on smooth muscle.[6]
From: International Journal of Pharmacology
(1) These are enzymes that break down cyclic nucleotides like cAMP and cGMP, and inhibitors of these enzymes, such as sildenafil and dipyridamole, can have various pharmacological effects.[7] (2) An enzyme, particularly PDE4, found in inflammatory and immunomodulatory cells, whose inhibition may impact various inflammatory diseases.[8] (3) Phosphodiesterase is an enzyme that is inhibited, potentially mediating antispasmodic and bronchodilator activities.[9]