Significance of Perineural invasion
Perineural invasion is defined as the infiltration of cancer cells along nerve fibers, serving as an indicator of aggressive tumor behavior, particularly in colorectal cancer (CRC). It is also recognized in malignant prostate cases, where its presence correlates with elevated Gleason scores. Additionally, perineural invasion is a notable pathological feature in adenoid cystic carcinoma, reflecting how cancer can spread along nerve pathways. Overall, perineural invasion signifies important insights into cancer progression and severity.
Synonyms: Perineural spread, Neural invasion
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Perineural invasion in scientific sources
Perineural invasion indicates cancer cell presence around and along nerves, linked to aggressive tumor behavior in various cancers, including prostate cancer and adenoid cystic carcinoma, and is associated with higher Gleason scores and malignancy risk.
From: The Malaysian Journal of Medical Sciences
(1) This is a way the tumor spreads, where it invades the nerves directly, and it contributes to the aggressive nature of the malignant peripheral nerve sheath tumor.[1] (2) The infiltration of cancer cells along nerve fibers, which is a marker for aggressive tumour behavior in CRC.[2]
From: Journal of Public Health in Africa
(1) A small proportion of cases presents this, a marker of aggressive disease and potential for pain or other neurological symptoms, according to the text.[3]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) 'Perineural invasion' refers to the spread of cancer cells along nerves, and MicroRNA-21 promotes this and impacts survival in patients with oral carcinoma.[4] (2) The spread of cancer cells into the nerves surrounding a tumor, an indicator of more aggressive disease.[5]