Significance of Particle size reduction
Particle size reduction is a vital technique in pharmaceuticals aimed at improving the solubility and bioavailability of poorly soluble drugs. By decreasing the size of drug particles, the method enhances their surface area, leading to better dissolution rates and absorption in the body. This process is particularly beneficial in the formulation of solid dispersions and nanosuspensions, where smaller particle sizes increase interaction with solvents, thereby facilitating improved drug delivery performance and therapeutic effectiveness.
Synonyms: Comminution, Milling, Grinding, Pulverization, Fragmentation, Size reduction, Micronization, Crushing
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Particle size reduction in scientific sources
Particle size reduction is crucial for enhancing drug solubility and bioavailability by decreasing particle sizes from microns to nanometers, thereby improving dissolution rates of poorly soluble drugs, such as itraconazole, during pharmaceutical processing.
From: World Journal of Pharmaceutical Research
(1) A method aimed at improving the dissolution and absorption of drugs by decreasing their particle size.[1] (2) The process of decreasing the size of drug particles to enhance solubility and therapeutic efficacy.[2] (3) A process aimed at decreasing the size of solid particles to enhance their properties and performance.[3] (4) A process that decreases the particle size of a poorly soluble compound to increase its surface area and improve dissolution rates.[4] (5) A process that decreases the size of drug particles to improve their dissolution rate and bioavailability.[5]
From: Ancient Science of Life
(1) The process of minimizing the size of particles in Mandura bhasma, which increases its absorption and therapeutic effectiveness.[6]
From: AYU (Journal of Research in Ayurveda)
(1) The significant decrease in the size of the grains from raw material (5-10 microns) to the final Bhasma product (50-200 nm) during the pharmaceutical process.[7]