Significance of Oxidative damage
Oxidative damage, according to the provided texts, consistently refers to cellular or tissue harm caused by an excess of reactive oxygen species (ROS) or free radicals. This damage affects various cellular components, including lipids, proteins, and DNA. The texts emphasize that oxidative damage is linked to several diseases and conditions, and is often mitigated by antioxidants. The texts show that oxidative damage can be caused by various factors, including drugs, environmental toxins, and metabolic processes.
Synonyms: Oxidative stress, Oxidative injury, Oxidative harm, Oxidative degradation, Free radical damage, Reactive oxygen species damage
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Oxidative damage'
In Hinduism, oxidative damage signifies harm caused by free radicals to cells and tissues. This damage is counteracted by antioxidants. It can affect various organs and tissues, including the brain, and is linked to factors like smoking and excess copper. Brahmi and Bala are mentioned for their protective effects.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) The text refers to harm caused by reactive oxygen species, which antioxidants can help prevent, indicating a protective mechanism.[1] (2) Oxidative damage is repaired by MSM - Methylsufonylmethane, which prevents neurological diseases. This process helps restore cell membrane elasticity.[2] (3) This refers to damage to cells and tissues caused by free radicals, which can be prevented by antioxidants found in certain drugs.[3] (4) This refers to harm caused to internal organs due to the presence of free radicals, where Bala is noted to have protective effects against this, as validated in animal studies.[4] (5) This phrase refers to the harm caused by the presence of reactive oxygen species, particularly in periodontal tissues, potentially resulting from factors such as smoking tobacco.[5]
From: International Research Journal of Ayurveda and Yoga
(1) Free radicals causes cellular damage through lipid peroxidation, DNA damages and this of proteins.[6] (2) Ashwagandha, Vacha, Brahmi improve antioxidant levels & reduce oxidative damage of nervous system.[7] (3) This is a condition prevented by Acorus Calamus extracts and Nickel Chloride in the rat kidney, indicating its potential to protect against cellular damage.[8] (4) This is caused by fat storage in hepatocytes, which can be prevented by the modulation of lipid metabolism, which is beneficial.[9]
From: Journal of Ayurvedic and Herbal Medicine
(1) Furthermore, flavonoids are useful exogenous agents in protecting the aging brain, other organs and tissues of the body against free-radical induced damage, as the text states.[10]
The concept of Oxidative damage in scientific sources
Oxidative damage is cellular harm caused by reactive oxygen species (ROS) and free radicals. This damage, affecting various tissues and biological systems, is linked to chronic diseases, aging, and impaired healing. Antioxidants can mitigate this damage, which can also be exacerbated by certain conditions and medications.
From: International Journal of Pharmacology
(1) Oxidative damage is caused by reactive oxygen species and is generally responsible for the side effects of methotrexate, this can be protected against with antioxidant agents.[11] (2) Oxidative damage is inhibited by folic acid, which also attenuates learning and memory impairment in hypothyroid rats, indicating the importance of reducing oxidative stress for cognitive function.[12] (3) "Oxidative damage" can be prevented and treated with TPL, which is also used in ionizing radiation, hypertension, nervous system injury, ischemiareperfusion injury and diabetes.[13] (4) Oxidative damage occurs when there is an imbalance between oxidants and antioxidants, and the administration of favipiravir to rats was found to induce oxidative damage in the lung tissue.[14] (5) Oxidative damage refers to the harm caused by an imbalance between free radicals and antioxidants in the body, against which thiamine pyrophosphate protects the liver tissue.[15]
From: Asian Journal of Pharmaceutics
(1) This is what cell membranes are protected against by tocopheryl acetate.[16] (2) This is harm to cells and tissues caused by an imbalance between free radicals and antioxidants.[17] (3) This is the injury caused by oxidative stress, which the study aims to reduce.[18] (4) Fruits in human diets might serve as possible protective agents to help reduce this.[19] (5) Treatment with Ketotifen blunted AKI-induced renal dysfunction in rat kidney and reduced this, showing Ketotifen may reduce glycerol-induced renal injury.[20]
From: The Malaysian Journal of Medical Sciences
(1) Oxidative damage within the muscle causes fatigue and decreased performance due to excess ROS attenuated by the consumption of fruit-derived polyphenols with antioxidant and anti-inflammatory properties, according to the provided text.[21] (2) The text reports that alkaline-reduced water protects DNA from this type of damage. This suggests that Zamzam water might also have this protective effect.[22] (3) This refers to the harm caused by reactive oxygen species, and its levels are measured to assess the impact of different interventions.[23] (4) This is damage caused to tissues, in this case brain tissue, by free radicals or reactive oxygen species, and it was examined in relation to ischemia and the effects of soy extract.[24] (5) This is a consequence of oxidative stress and the generation of free radicals, and it is associated with the pathogenesis of cardiovascular diseases.[25]
From: Journal of Medicinal Plants for Economic Development
(1) Damage to cells caused by free radicals, which can be reduced by treatments that protect the liver, as stated in the text.[26] (2) These are damages that curcumin could inhibit, caused by chronic stress in vital organs, including the brain, liver and kidney.[27] (3) This to spermatozoa and oocytes is the topic of an update by Opuwari & Henkel (2016), focusing on the issue.[28] (4) The text indicates that oxidative damage in the intestine of diabetic rats is evidenced by the increase in H2O2 levels and MDA content.[29]
From: Onderstepoort Journal of Veterinary Research
(1) This refers to the harm caused to cells and molecules by unstable molecules, and is a mechanism by which toxins can cause damage.[30] (2) Oxidative damage is cellular harm caused by reactive oxygen species, and in this study, it is linked to the effects of aflatoxin B1, which leads to an increase in serum enzyme levels as an indicator of this damage.[31] (3) This type of damage can be induced by free radicals and cortisol, which AA helps to prevent by protecting blood cells such as heterophils and lymphocytes.[32]
From: South African Family Practice
(1) Can be repaired to biomolecules by antioxidants, and antioxidants can influence and upregulate repair enzymes.[33]
From: Journal of Metabolic Health
(1) It can be induced by high-fructose-induced copper deficiency in rats, and may not be wholly iron dependent, possibly via lower ceruloplasmin concentrations.[34]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) It is damage caused by oxidative stress, and the work of Chung and colleagues provides a link between this and the role of parkin in sporadic Parkinson's disease.[35] (2) Oxidative damage can be exacerbated by arsenite, as it inhibits the production of enzymatic scavengers, affecting the detoxification processes in phytoplankton and plants.[36] (3) Toxic metals and oxidative stress part I: Mechanisms involved in metal-induced oxidative damage are mentioned.[37] (4) Oxidative Damage is a consequence studied in relation to tobacco smoke, with research elucidating the role of oxidative stress in tobacco-smoke-induced toxicity and carcinogenicity.[38] (5) Recent findings have demonstrated that oxidative damages contribute to the cytotoxicity and carcinogeneticy of mycotoxins such as ochratoxin A, aflatoxin B 1 (AfB 1), fumonisin B 1 and Zearalenone.[39]
From: Sustainability Journal (MDPI)
(1) Damage to cells caused by an excess of free radicals, which results in an increase in the IBRv2 index, calculated based on biomarkers.[40] (2) Oxidative damage can be induced by heavy metals and excessive illumination, leading to the generation and accumulation of superoxide radicals in plant tissues.[41] (3) Nitrogen supply significantly enhanced the drought tolerance of grass plants, which was attributed to the promotion of antioxidant metabolism and nitrogen metabolism, thereby safeguarding cell membranes against oxidative damage.[42] (4) Oxidative damage is the harm caused by reactive oxygen species, and the dual action of the extract would mitigate oxidative damage caused by environmental stressors.[43] (5) Rice plants protect themselves against this using two mechanisms: (i) the presence of antioxidant enzyme systems, (ii) natural antioxidants.[44]
From: International Journal of Pharmacology
(1) Cellular harm caused by an imbalance of free radicals and antioxidants, which acrolein can both produce and initiate.[45] (2) Damage to cells caused by an imbalance of free radicals and antioxidants, which can be reduced by antioxidants like Trolox.[46] (3) Cellular damage caused by reactive oxygen species, which can be mitigated by antioxidants like those found in Phoenix dactylifera L.[47] (4) Damage to cellular components, including DNA, proteins, and lipids, caused by reactive oxygen species, which contributes to the loss of structural integrity.[48] (5) Harm to cells and tissues resulting from an imbalance of free radicals and antioxidants.[49]