Significance of Oral submucous fibrosis
Oral submucous fibrosis (OSMF) is a chronic and potentially malignant disorder of the oral cavity, primarily linked to areca nut and tobacco chewing. Characterized by symptoms such as stiffness in the oral mucosa, burning sensations, and restricted mouth opening, OSMF can lead to significant functional impairments, including difficulties with eating and swallowing. As a chronic condition, OSMF also carries a risk of malignant transformation and is marked by progressive fibrosis and inflammatory reactions in the oral tissues.
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The concept of Oral submucous fibrosis in scientific sources
Oral submucous fibrosis is a chronic condition impacting the oral cavity, marked by inflammation and fibrosis, causing mouth rigidity and reduced opening. It is noted as a significant lesion in evaluated subjects, representing a potential premalignant disease.
From: The Malaysian Journal of Medical Sciences
(1) This is a condition where c-KIT is more accurate in determining mast cell density, as confirmed by a study that compared mast cell densities using c-KIT and toluidine blue stains.[1]