Significance of Nucleoside analogue
Nucleoside analogues are a class of antiviral drugs that mimic the building blocks of DNA or RNA, interfering with viral replication. In health sciences, they are essential in antiretroviral combinations for HIV treatment, including medications like stavudine. These drugs also play a role in hepatitis B treatment and target viral RNA synthesis. Resistance to these drugs develops slowly, with the exception of 3TC, though they are associated with lactic acidosis, a rare but serious complication.
Synonyms: Nucleoside analog, Nucleotide analogue, Antiviral agent
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Nucleoside analogue'
In Hinduism, nucleoside analogues are antiviral drugs hindering viral replication. These medications are utilized to combat illnesses caused by viruses. They are a modern scientific intervention to protect health and well-being.
From: Journal of Ayurvedic and Herbal Medicine
(1) These are drugs that interfere with the virus's ability to replicate, which can be used as antivirals.[1]
The concept of Nucleoside analogue in scientific sources
Nucleoside analogues are antiviral medications, like stavudine and acyclovir, that interfere with viral replication. They mimic DNA/RNA building blocks, disrupting synthesis. Used in HIV and hepatitis B treatment, resistance is slow to develop, though some may cause lactic acidosis.
From: South African Journal of HIV Medicine
(1) Antiretroviral nucleoside and nucleotide analogues can affect mitochondria, as discussed in a publication in AIDS, emphasizing the importance of understanding their impact.[2] (2) These are a class of drugs that continue to form the backbone of most antiretroviral combinations used in HIV treatment.[3] (3) A class of antiretroviral drugs, and resistance to nucleoside analogues is slow to develop, with the exception of 3 TC.[4] (4) Resistance to these is slow to develop, with the exception of 3TC, and all have been associated with lactic acidosis, which is a rare but potentially life-threatening metabolic complication of treatment.[5] (5) These are a type of medication, including stavudine, that are used as antiretrovirals and work by interfering with the virus's ability to replicate, and are associated with higher CD4 cell count responses.[6]
From: Asian Journal of Pharmaceutics
(1) Zidovudine (AZT) is this type of reverse transcriptase inhibitor, which is used as antiviral medication.[7] (2) Synthetic compounds that mimic natural nucleosides and are used as antiviral or anticancer drugs.[8]
From: The Malaysian Journal of Medical Sciences
(1) A type of antiviral drug that mimics nucleosides in order to disrupt viral RNA synthesis, such as balapiravir targeting NS5.[9]
From: South African Family Practice
(1) These are drugs, including acyclovir and its derivatives, that inhibit the synthesis of HSV DNA and have been developed since the discovery of acyclovir.[10]
From: International Journal of Pharmacology
(1) Research has explored the effects of nucleoside analogues on enzyme activities, including their potential to inhibit paraoxonase.[11]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Nucleoside analogues are substances that structurally resemble nucleosides, and they have been identified as a potential treatment that can be used to treat patients.[12]