Significance of Nrf2 signaling pathway
The Nrf2 signaling pathway is a cellular defense mechanism crucial for regulating antioxidant and detoxifying enzymes. It protects against oxidative stress and is activated by compounds like quercetin and DADS. Curcumin targets this pathway to counter ketamine-induced oxidative stress. The pathway's activation involves p62 through selective autophagy. Influencing the Nrf2 signaling pathway, as seen with Tao Hong Si Wu decoction, can protect against cerebral ischemia-reperfusion injury.
Synonyms: Oxidative stress response, Antioxidant response element
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Nrf2 signaling pathway in scientific sources
The Nrf2 signaling pathway is a cellular defense mechanism. It regulates antioxidant protein expression, protects against oxidative stress and DNA damage, and is activated by compounds like curcumin, quercetin, and DADS.
From: International Journal of Pharmacology
(1) A pathway activated by chlorogenic acid, reversing ROS-mediated neurotoxicity, as indicated in the provided text.[1] (2) The Nrf2 signaling pathway is a cellular defense mechanism that regulates the production of antioxidant and detoxifying enzymes, playing a role in protecting against oxidative stress.[2] (3) Tao Hong Si Wu decoction protects against cerebral ischemia-reperfusion injury by influencing the PI3K/Akt and Nrf2 signaling pathways.[3] (4) DADS was found to regulate the activation of this pathway.[4]
From: International Journal of Pharmacology
(1) A cellular pathway that regulates the expression of antioxidant proteins, which curcumin targets to reduce ketamine-induced oxidative stress.[5] (2) A cellular pathway that regulates the expression of antioxidant proteins, which is activated by quercetin to prevent DNA damage.[6]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) The Nrf2 signaling pathway has pivotal roles in inflammation, and this is how antioxidants work.[7]