Significance of Neuritic plaques
Neuritic plaques are extracellular deposits of amyloid-beta protein that disrupt neuron function and are commonly associated with Alzheimer's disease. These amyloid aggregates are formed from the accumulation of beta-amyloid peptides, acting as key pathological markers of the disease. The presence of these abnormal protein clusters in the brains of individuals with Alzheimer's contributes significantly to cognitive decline, highlighting their critical role in the progression of the condition.
Synonyms: Senile plaques
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Neuritic plaques in scientific sources
Neuritic plaques are abnormal protein clusters in Alzheimer's patients' brains, comprised of beta-amyloid peptide aggregates, and are key contributors to the cognitive decline characteristic of the disease.
From: World Journal of Pharmaceutical Research
(1) Clusters of beta-amyloid peptides that accumulate outside neurons in Alzheimer’s disease, contributing to cognitive decline.[1] (2) Extracellular deposits of abnormally accumulated amyloid-beta protein that disrupt neuron function and are associated with Alzheimer's disease.[2] (3) Amyloid aggregates formed from the deposition of beta-amyloid peptides, serving as pathological hallmarks of Alzheimer's disease.[3]
From: International Ayurvedic Medical Journal
(1) Abnormal clusters of protein fragments found in the brains of Alzheimer's patients, contributing to cognitive decline.[4]