Significance of Myeloperoxidase
Myeloperoxidase, an enzyme, is discussed extensively in both Science and Health Sciences. Science highlights it as an enzyme in human leukocytes, whose activity increases with aluminum chloride treatment, and that can have both beneficial and detrimental effects. Health Sciences links it to inflammation, frequently used in studies for conditions like rheumatoid arthritis, and as a biomarker for inflammation in various tissues, including the heart, colon, and gastric tissue. It is also linked to the oxidation of LDL and exposure to toxic substances.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Myeloperoxidase in scientific sources
Myeloperoxidase (MPO) is an enzyme primarily found in neutrophils. It plays a key role in inflammation by catalyzing the formation of toxic hypochlorous acid. MPO activity is a marker for inflammation and is used to assess inflammatory responses in various tissues. Its levels can be influenced by factors like oxidative stress and exposure to toxins.
From: International Journal of Pharmacology
(1) Myeloperoxidase-initiated LDL oxidation is promoted by salicylate, as detailed in the text.[1] (2) This activity was estimated by Suzuki et al.[2] (3) An enzyme that catalyzes the reduction of peroxides and the most reliable index for evaluating aggregation.[3] (4) Also known as MPO, the activity of this in the total homogenate was measured according to the method of Wei and Frenkel.[4] (5) This is a substance that was measured in the excised brain tissues for biochemical analysis.[5]
From: Asian Journal of Pharmaceutics
(1) An enzyme whose levels are measured to assess inflammation.[6] (2) An enzyme, abbreviated as MPO, its levels increase during inflammation, used as a marker to assess colitis severity.[7] (3) This is a keyword mentioned in the text as one of the keywords of the study.[8]
From: The Malaysian Journal of Medical Sciences
(1) An enzyme involved in inflammation, and its activity was measured to assess the inflammatory response in the liver.[9]
From: Journal of Medicinal Plants for Economic Development
(1) This is an enzyme released by white blood cells and its levels were measured to assess the effect of the extract on inflammation in the heart tissue.[10]
From: International Journal of Pharmacology
(1) An enzyme found in human polymorphonuclear leukocytes, for which a specific assay method exists.[11] (2) A heme-containing peroxidase highly expressed in neutrophils, which, when stimulated, can lead to lipid adducts and kidney dysfunction through the MPO-hydrogen peroxide-chloride system.[12] (3) Myeloperoxidase is an enzyme activity that is significantly increased in the liver following aluminum chloride treatment, and this increase is also observed when combined with blackberry or quercetin.[13] (4) Myeloperoxidase is an enzyme that functions as both a beneficial component and a detrimental factor within biological systems.[14]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) is an inflammatory parameter that was positively correlated with soluble ST2. It is involved in chronic inflammatory conditions and promotes additional endothelial dysfunction.[15] (2) It is an enzyme measured as a biomarker in peri-implant crevicular fluid to assess neutrophil activity and inflammation.[16] (3) It is a protein involved in redox homeostasis and is found among the additional differentially expressed proteins after PM 2.5 exposure, also related to phagosomes.[17] (4) In the bone marrow, HQ and catechol are converted by this to 1,4-benzoquinone, contributing to benzene-induced hematotoxicity.[18]