Significance of Multiple reaction monitoring

Multiple reaction monitoring is a mass spectrometry technique designed for the selective detection and quantification of specific analytes by monitoring unique ion transitions. This method enhances sensitivity and specificity, allowing for accurate detection of compounds in complex samples, such as flubendazole and sirolimus. It involves simultaneous monitoring of multiple ion transitions to improve analytical data collection and is particularly beneficial in characterizing substances like imatinib and remdesivir, making it essential for impurity quantification and overall analytical precision.

Synonyms: Mrm, Selected reaction monitoring, Quantitative analysis

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The concept of Multiple reaction monitoring in scientific sources

Science Books

Multiple reaction monitoring (MRM) is a mass spectrometry technique that enhances sensitivity and specificity by detecting specific ion transitions, allowing for precise quantification of compounds like sirolimus, imatinib, and desmethyl imatinib.

Significance in Scientific journals, articles, etc.:

From: World Journal of Pharmaceutical Research

(1) A technique in mass spectrometry used to improve the sensitivity and specificity of a method by monitoring specific ion transitions.[1] (2) A mass spectrometry technique that monitors specific product ions from precursor ions to enhance the detection of targeted compounds.[2] (3) An analytical technique that monitors multiple ion transitions simultaneously for enhanced data collection.[3] (4) A mass spectrometry technique that allows the detection of specific ion transitions for quantification of remdesivir and GS-441524.[4] (5) A mass spectrometry technique used to quantify specific ions in a mixture, particularly useful for characterizing degradation products.[5]

From: AYU (Journal of Research in Ayurveda)

(1) A mode in mass spectrometry that enhances sensitivity by monitoring specific ion transitions corresponding to the compounds of interest.[6]

This section includes scientific research in the field of healthcare, often involving traditional medicine systems such as Ayurveda, Unani, Siddha and Holistic health. It includes papers from scientific journals classified as either original, clinical or experimental research, review articles or case reports.