Significance of MRNA expression
mRNA expression refers to the level of messenger RNA for specific genes. It is a critical process where genetic information is transcribed from DNA into mRNA, which then directs protein synthesis. Measuring mRNA expression, often using techniques like RT-PCR, helps determine gene activity, reflecting the extent of transcription and potentially, translation. Changes in mRNA expression can indicate altered cellular activity and are used to study various biological processes, including responses to treatments and disease mechanisms.
Synonyms: Gene expression, Messenger rna expression, Transcription levels, Rna synthesis
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of MRNA expression in scientific sources
mRNA expression is the level of messenger RNA produced from specific genes, reflecting gene activity. It is measured using techniques like RT-PCR and qRT-PCR to understand biological processes, the impact of treatments, and the cellular response in various tissues and diseases.
From: International Journal of Pharmacology
(1) The "mRNA expression" of various inflammatory markers like COX-2, iNOS, TNF-α, IL-1β, and IL-6 is examined to assess the impact of LPS and iridium compounds on the inflammatory response in microglia cells.[1] (2) mRNA expression refers to the levels of messenger RNA for specific genes, such as BDNF, CaMK, CREB, ERK, and PI 3K, which are altered by scopolamine and modulated by boswellic acid.[2] (3) The MET increases the mRNA expression level of vdj-Cα in B cells in vitro, implying that MET promoted the secretion of IgA by B cells.[3]
From: Asian Journal of Pharmaceutics
(1) Relative levels were calculated and compared with Pioglitazone, a known insulin sensitizer.[4] (2) This complex had no effect on ABCB 1 A and ABCB 1 B mRNA expression; however, it down-regulated berberine-up-regulated P-gp this.[5] (3) Nonparametric Wilcoxon test was used to compare differences of target and reference genes in ccRCC samples.[6]
From: Journal of Public Health in Africa
(1) The expression of APOBEC 3 G mRNA was quantified in both HIV-positive and HIV-negative subjects, as part of the investigation into its role in HIV-1 infection.[7]
From: The Malaysian Journal of Medical Sciences
(1) mRNA expression refers to the process by which messenger RNA molecules are produced from DNA, and the differential mRNA expression showed key under-expressed genes.[8] (2) This refers to the level of messenger RNA produced from a gene, which indicates the level of gene activity.[9] (3) This describes the process of transcribing mRNA and can be linked to the process of ageing, with countless changes discussed in various species.[10]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) The greatest inflammatory responses in mice exposed to straw storage hall dust included 30 to 60-fold elevations in mRNA expression for specific cytokines in lung tissue.[11] (2) The mRNA Expressions of p 22 phox and p 47 phox in Myocardium were significantly elevated in both mouse strains after exposure to the high-dose PM 2.5 compared to the baseline control condition.[12] (3) The quantity of messenger ribonucleic acid present in cells, which reflects the level of gene activity, specifically studied for changes related to the absence of social contact in certain small mammals.[13]
From: International Journal of Pharmacology
(1) This is the level of mRNA expression of aldose reductase, which is assessed to understand the impact of treatments on the enzyme's activity.[14]
From: International Journal of Pharmacology
(1) In situ hybridization allowed for direct comparison of mRNA expression levels across different experimental groups.[15] (2) The level of gene expression, evaluated using RT-PCR for ROCK1 and SIRT1 in experimental studies on nattokinase.[16] (3) mRNA expression refers to the process by which genetic information is transcribed into messenger RNA, which can be regulated by anti-inflammatory compounds.[17]