Significance of MDA-MB-231
MDA-MB-231 is a human breast cancer cell line commonly utilized in laboratory studies to assess the cytotoxic effects of various substances. This cell line has applications in evaluating the efficacy of anti-cancer drugs, plant extracts, synthesized compounds, and even silver nanoparticles. It plays a crucial role in in vitro tests, particularly due to its non-hormone-dependent nature, making it a standard choice for researchers examining antiproliferative properties and the cytotoxic activity of different treatments.
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The concept of MDA-MB-231 in scientific sources
MDA-MB-231 is a human breast cancer cell line employed in research to assess the antiproliferative effects of plant extracts and to evaluate the cytotoxicity of synthesized silver nanoparticles, highlighting its significance in cancer studies.
(1) MDA-MB-231 cells are classified as the luminal B molecular subtype and a triple negative breast cancer cell line that has low or no expression of certain markers.[1] (2) This is a human breast cancer cell line used in the MTT assay to evaluate the cytotoxic activity of the tamarillo extract and its fractions.[2] (3) A non-hormone-dependent breast cancer cell line included in the research study for testing Clausine B's effects.[3]
(1) A human breast cancer cell line utilized in the study, characterized by high expression of human PD-L1 protein.[4] (2) A human breast cancer cell line that showed potent growth inhibition by vernodalin, an isolated compound from C. anthelminticum.[5] (3) MDA-MB-231 is a human breast cancer cell line that specifically represents the Triple-Negative Breast Cancer subtype and is frequently utilized in foundational research studies.[6]