Significance of Matrix metalloproteinase
Matrix metalloproteinases (MMPs) are a group of zinc-dependent enzymes critical for the degradation of extracellular matrix components. They play essential roles in various biological processes, including tissue remodeling, inflammation, and disease progression. MMPs are implicated in conditions such as periodontal disease, skin aging, cancer metastasis, and arthritis. Specific enzymes like MMP-2 and MMP-9 are prominently involved in matrix breakdown, influencing tissue destruction and repair mechanisms. Their activity can be modulated by various factors, making them significant in both health and disease contexts.
Synonyms: Mmp, Proteolytic enzyme, Collagenase, Metalloenzyme, Enzyme, Protease
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The concept of Matrix metalloproteinase in scientific sources
Matrix metalloproteinase (MMP) is a group of enzymes crucial for degrading extracellular matrix components such as collagen, playing significant roles in conditions like arthritis and periodontal disease, where tissue destruction occurs.
(1) These are enzymes that break down the extracellular matrix, which can be affected by certain substances to impact cell proliferation.[1] (2) Matrix metalloproteinases are enzymes, and leptin has been shown to activate these proteases.[2] (3) These are pre-formed and are released, which modulate extracellular matrix formation, and MMP-9 is one of them.[3] (4) MMP9 is a component of this family, which is responsible in degrading the extracellular matrix, and its high expression correlates with aggressive gliomas.[4] (5) A family of enzymes that break down proteins in the extracellular matrix, and their activity is associated with the development of atherosclerosis and stroke.[5]