Significance of Lower Limit of Quantification

The Lower Limit of Quantification (LLOQ) is defined as the lowest concentration of an analyte that can be reliably quantified using a specific analytical method. It is characterized by requiring acceptable precision and accuracy, generally set at a level where the precision (relative standard deviation) is better than 20% and the accuracy (bias) is lower than 20%. For instance, the LLOQ for Clofarabine is established at 0.092 ng/mL, while for Carbodenafil and Des-methyl Carbodenafil, it is set at 2.00 ng/mL.

Synonyms: Loq, Detection limit

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The concept of Lower Limit of Quantification in scientific sources

Science Books

The Lower Limit of Quantification (LLOQ) is the minimum concentration of an analyte that an analytical method can accurately and precisely measure, ensuring reliable results in quantitative assessments, according to regional sources.

Significance in Scientific journals, articles, etc.:

(1) The smallest concentration of Venlafaxine hydrochloride that can be reliably measured by the analytical method.[1] (2) The lowest concentration of a substance that can be reliably quantified by a particular analytical method, here defined as 5 ng/mL.[2] (3) The lowest concentration at which the precision expressed by relative standard deviations (RSD, CV %) is better than 20% and the accuracy (bias) expressed by the relative difference of the measured and true value is also lower than 20%.[3] (4) The lowest concentration of an analyte that can be reliably quantified by an analytical method.[4] (5) The lowest concentration of an analyte that can be reliably quantified through a specific analytical method.[5]

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