Significance of Limit of Quantification (LOQ)
The Limit of Quantification (LOQ) is defined as the lowest concentration of a substance that can be quantitatively measured with acceptable precision and accuracy in analytical methods. It is crucial for determining the reliable quantification of various analytes, ensuring consistent performance in testing. Specific examples include LOQ values for Moxidectin at 0.08 µg/ml, Norfloxacin at 1.353 µg/ml, Ezetimibe at 0.65 µg/ml, and others, showcasing LOQ's role in assessing different substances with specified methodologies.
Synonyms: Detection limit, Lower limit of quantification, Quantitation limit
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The concept of Limit of Quantification (LOQ) in scientific sources
The Limit of Quantification (LOQ) defines the lowest concentration of an analyte that can be reliably quantified in a sample, ensuring acceptable precision and accuracy under specific experimental conditions.
From: World Journal of Pharmaceutical Research
(1) The lowest concentration of the drug that can be quantitatively measured, found to be 0.619 µg/mL in this study.[1] (2) The lowest concentration of Lamivudine that can be reliably quantified using the developed method, aligned with ICH definitions.[2] (3) The lowest concentration of a substance that can be quantitatively determined with acceptable precision and accuracy.[3] (4) The lowest concentration of Moxidectin that can be quantitatively measured with acceptable precision and accuracy, set at 0.08 µg/ml.[4] (5) The lowest concentration of Fluconazole that can be quantitatively determined with acceptable precision and accuracy, found to be 4.82 μg/ml.[5]
From: International Ayurvedic Medical Journal
(1) The minimum concentration of an analyte that can be quantified with acceptable precision and accuracy under the stated experimental conditions.[6]