Significance of Limit of Detection (LOD)
Limit of Detection (LOD) is defined as the lowest concentration of a substance that can be reliably detected by analytical methods, although quantification is not guaranteed. Various studies have established specific LOD values for different substances, such as 0.351 μg/ml for a particular analyte, 0.21 µg/ml for Ezetimibe, and 1.59 μg/ml for Fluconazole. LOD signifies the sensitivity of an analytical method and ensures reliable detection of substances under the experimental conditions specified.
Synonyms: Detection limit, Limit of quantification, Detection threshold, Sensitivity limit
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The concept of Limit of Detection (LOD) in scientific sources
Limit of Detection (LOD) is defined as the lowest analyte concentration reliably detectable by an analytical method, significant for assessing sensitivity, and emphasizes the distinction between detection and quantification capabilities in sample analysis.
From: International Journal of Pharmacology
(1) The limit of detection (LOD) was defined as the concentration yielding a signal-to-noise ratio of three to one.[1]