Significance of Limit of detection
The Limit of Detection (LOD) is defined as the lowest concentration of an analyte that can be reliably detected, though not necessarily quantified. This measurement is crucial in assessing the sensitivity of analytical methods. Various substances, including Ezetimibe, Simvastatin, and others, have established LOD values, often given as specific concentrations under certain experimental conditions. The LOD varies among compounds, indicating the importance of method development for accurate detection in pharmaceutical analyses.
Synonyms: Detection threshold, Sensitivity limit, Detection limit, Threshold, Sensitivity, Analytical sensitivity
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The concept of Limit of detection in scientific sources
The Limit of Detection (LOD) signifies the minimal concentration of a substance that can be accurately identified in a sample, though it may not always be quantifiable, as outlined by regional sources.
From: World Journal of Pharmaceutical Research
(1) Limit of detection (LOD) refers to the smallest concentration of a substance that can reliably be detected, while still not necessarily being quantifiable.[1] (2) The lowest concentration of Azelnidipine that can be reliably detected by the method, found to be 0.024 µg/ml.[2] (3) The minimum concentration of Oxaprozin that can be reliably detected by the developed HPLC method.[3] (4) The lowest concentration of Vericiguat that can be reliably detected in the analysis by the developed method, determined to be 6.6 µg/mL.[4] (5) The lowest concentration that can be reliably detected, determined to be 1.38 µg/ml for Lisinopril and 0.91 µg/ml for Carvedilol.[5]
From: AYU (Journal of Research in Ayurveda)
(1) The lowest concentration of a substance that can be reliably detected but not necessarily quantified under the stated conditions.[6] (2) The lowest concentration of a substance that can be reliably detected in a sample.[7]
From: Journal of Ayurveda and Integrative Medicine
(1) The lowest quantity of a substance that can be reliably detected in an analysis.[8]