Significance of Interleukin-4
Interleukin-4 (IL-4) is a multifaceted cytokine. In the realm of Science, it's linked to allergic diseases like asthma and plays a role in gene expression within T cells and Th2 immune responses, potentially impacting arthritis. Health Sciences views IL-4 as an anti-inflammatory cytokine, increasing during inflammatory diseases, activating M2-type macrophages, and promoting tissue repair. It stimulates IgE production, B cell differentiation, and regulates immune responses, contributing to tissue healing and inhibiting pro-inflammatory cytokines.
Synonyms: Il-4, Cytokine, Immune regulator
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Interleukin-4 in scientific sources
Interleukin-4 (IL-4) is a cytokine with diverse roles in the immune system. It can be anti-inflammatory, promoting tissue repair and suppressing pro-inflammatory cytokines. IL-4 also regulates immune responses, influences T and B cell activity, and is associated with allergic diseases and arthritis.
From: International Journal of Pharmacology
(1) Interleukin-4 is an anti-inflammatory cytokine that is observed to increase during inflammatory diseases, contributing to the overall inflammatory response.[1] (2) Interleukin-4 (IL-4) is an inflammatory cytokine that primarily activates M2-type macrophages, playing a role in tissue repair and wound healing.[2]
From: Journal of Public Health in Africa
(1) This is a cytokine that is produced by Th 2 cells and stimulates IgE production, as well as the development of CD 4+ naive cells.[3]
From: Onderstepoort Journal of Veterinary Research
(1) Interleukin 4 (IL-4) is a Th2 cytokine that is assessed for its induction via enzyme-linked immunospot (ELISpot) when evaluating subfragments expressed in an Escherichia coli host expression system.[4]
From: Asian Journal of Pharmaceutics
(1) It is a cytokine, and its concentrations were notably higher in the patients in the acute cholecystitis group according to the text.[5]
From: International Journal of Pharmacology
(1) A Th2 cytokine that is associated with allergic diseases like bronchial asthma when excessively activated.[6] (2) A cytokine often associated with Th2 immune responses, which can play a role in arthritis development.[7] (3) Interleukin-4 is implicated in modulating gene expression within T cells, influencing cytokine production and cellular responses.[8]