Significance of Inflammatory cytokines
Inflammatory cytokines are important signaling molecules released during immune responses that promote inflammation and play a significant role in various health conditions. They are produced by immune cells and contribute to pain, tissue damage, and disease progression in disorders like sciatica, osteoarthritis, and diabetes. Inflammatory cytokines, such as TNF-α and IL-1, are involved in the inflammatory response and can influence physiological functions, making them key targets for therapeutic interventions in chronic inflammatory diseases.
Synonyms: Immune mediators, Signaling proteins, Cytokine mediators, Cell signaling proteins
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The concept of Inflammatory cytokines in scientific sources
Inflammatory cytokines are signaling molecules that enhance inflammation and are often found at elevated levels in chronic conditions like diabetes, indicating their role in the pathophysiology of such diseases.
(1) Inflammatory cytokines are substances, such as TNF-α, IL-6, and IL-12, whose induction is triggered by the stimulation of TLRs by microbial components.[1] (2) These are signaling molecules that are involved in inflammation, and they mediate the recruitment and activation of eosinophils.[2] (3) These are substances, such as TNFα, that are released during kidney damage and contribute to the progression of chronic kidney disease.[3] (4) It was suggested that the association between RDW and adverse health outcomes could be related to increased oxidative stress and these, and pro-inflammatory cytokines have been proven to inhibit erythropoietin-induced maturation and proliferation of erythrocytes.[4] (5) Several inflammatory cytokines also trigger ACE2 up-regulation, which in turn may affect ACE2 expression due to smoking-related lung inflammation.[5]