Significance of In vitro model
In vitro models, according to the provided text, are experimental systems or laboratory methods conducted outside of a living organism. These models, often involving cells, tissues, or biological molecules in controlled environments, are used to study a wide range of biological processes. They serve various purposes, including assessing the effects of substances like plant extracts, drugs, or other compounds, evaluating biological activities such as antioxidant or anti-inflammatory effects, and understanding mechanisms of action. These models are also employed for preliminary drug testing and the study of various applications.
Synonyms: Laboratory model, Experimental model, Artificial model, Cell culture model, Cell culture, Experimental system
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'In vitro model'
In Hinduism, the "In vitro model" represents controlled experiments outside a living organism. Studies using these models, like those involving Piper longum, assess a plant's safety and potential applications. This method helps determine a plant's viability in various systems and research areas.
From: Journal of Ayurvedic and Herbal Medicine
(1) The bioavailability can be analysed with these which may mimic how it might act in vivo.[1] (2) The text refers to ‘Antinociceptive and Antioxidant Activities of Phytol in vivo and in vitro Models’.[2] (3) These are experiments conducted in a controlled environment outside of a living organism, and the text mentions the use of these models to study the effects of Piper longum on various systems.[3]
From: Journal of Ayurveda and Integrated Medical Sciences
(1) These are models where the plant extract exhibited absolute safety, which is an important aspect in determining the plant's potential in various applications and research areas.[4]
The concept of In vitro model in scientific sources
An *in vitro* model is a laboratory experiment conducted outside a living organism. It utilizes controlled environments, such as cells or tissues, to study biological processes like antioxidant activity, drug effects, or infection mechanisms. These models are crucial for preliminary research and often involve testing substances or analyzing their interactions.
From: International Journal of Pharmacology
(1) In vitro model A549 is used to evaluate the impact of microplastics in the air, according to the information presented in the text.[5] (2) The OGD in brain tissues is mostly under consideration as this of cerebral ischemia that permits for the valuation of neuronal collapse.[6] (3) This assay was adopted from the literature by Wu and Yen (2005) and used as this.[7]
From: Asian Journal of Pharmaceutics
(1) A disadvantage of SMEDDS is the lack of this model for assessment of the formulations.[8] (2) This is a model system used to study the effects of epigallocatechin gallate on methylglyoxal-induced amyloidogenesis.[9] (3) This refers to experiments conducted in a controlled environment outside of a living organism.[10]
From: Onderstepoort Journal of Veterinary Research
(1) A model that assumes sporozoites are live or dead, i.e., infective or not, and is used to assess the infectivity of stabilates and is considered more ethical and cheaper than in vivo testing.[11] (2) This is the cell line used to evaluate cytotoxicity induced by sesquiterpene lactones, which could be used in future studies to evaluate the effects of other compounds.[12]
From: Journal of Medicinal Plants for Economic Development
(1) In vitro model refers to an experimental model based on cell culture, used to screen for hypoglycaemic and insulin-modulating effects.[13]
From: The Malaysian Journal of Medical Sciences
(1) These can be developed with the use of the OTC-I scaffolds, which can be suitable as scaffolds for developing tissue substitutes for clinical applications and for in vitro models.[14] (2) This is a laboratory setting used to study biological processes, and this study aims to determine the expression of miR-3099 in this model.[15] (3) A controlled experimental setup outside a living organism, usually in a lab setting, to study biological processes.[16]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) These models were used to study the effect of radiofrequency electromagnetic field exposure on neurodegenerative disease.[17] (2) A range of in vitro models of the human intestinal tract have been developed over the years to allow for the investigation of metabolic transformations at specific locations within the system.[18] (3) The availability of **In Vitro Models** for Human Satellite Cells from Skeletal Muscle is highlighted, providing tools for studying muscle biology.[19]
From: International Journal of Pharmacology
(1) In vitro models, such as isolated rat fundus and rabbit jejunum preparations, were employed in this study to investigate the spasmolytic effects of herbal extracts.[20] (2) A controlled experimental setting using cells or biological molecules outside of a living organism, employed here to study the effects of drugs on liver cells.[21] (3) In vitro models are experimental systems used in laboratory settings to study biological processes, such as the antioxidant activity of plant extracts.[22]