Significance of In vitro drug release
In vitro drug release refers to the experimental procedures conducted in controlled laboratory settings to evaluate how a drug is released from its formulation. This includes measuring the rate and extent of drug release from various delivery systems, such as nanoparticles, transdermal patches, and microspheres, under conditions that simulate physiological environments. Such testing is crucial for assessing the performance and effectiveness of drug formulations in vivo, providing insights into their behavior and efficacy outside of living organisms.
Synonyms: In vitro dissolution, In vitro assay
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The concept of In vitro drug release in scientific sources
In vitro drug release involves laboratory testing to measure how medications, like carvedilol, are released from various formulations, including transdermal patches and tablets, under controlled conditions, providing essential performance data for drug development.
From: World Journal of Pharmaceutical Research
(1) The study of the rate and extent to which a drug is released from its dosage form in a controlled environment, mimicking physiological conditions.[1] (2) The process of assessing how a drug is released from its dosage form in a controlled laboratory environment, simulating the gastrointestinal conditions.[2] (3) A laboratory test that measures the rate and extent of drug release from the microspheres under controlled conditions.[3] (4) The evaluation of how a drug is released from its formulation in controlled experimental conditions, simulating internal biological environments.[4] (5) Laboratory studies assessing the rate and amount of drug released from a formulation in a controlled environment.[5]
From: Ancient Science of Life
(1) A laboratory method used to measure the release rate of a drug from a formulation under simulated biological conditions.[6]