Significance of IC50 value
IC50 value is a critical measure in pharmacology and biochemistry that refers to the concentration of a substance needed to inhibit a specific biological or biochemical function by 50%. It is used to gauge potency and effectiveness, particularly in evaluating substances for their cytotoxicity, antioxidant activity, and overall efficacy. The IC50 value indicates the degree of inhibition of biological processes, with lower values reflecting higher potency. This measure is essential for assessing the effectiveness of various compounds, including extracts and drugs.
Synonyms: Half-maximal inhibitory concentration, Ic50
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of IC50 value in scientific sources
The IC50 value is a critical metric indicating the concentration needed to inhibit biological processes by 50%, essential for quantifying the effectiveness of substances like VMD extract in antioxidant and anti-inflammatory activities.
From: The Malaysian Journal of Medical Sciences
(1) These are the virus titer values that are required to destroy half of the tumor cells in an experiment, based on MTT assays.[1] (2) This is the inhibitory concentration to inhibit growth at 50%, which indicates the concentration of the extract needed to inhibit parasite growth by 50%.[2] (3) These values of the drugs were determined by probit regression analysis, and they are used to measure the antimalarial activity of ellagic acid and other drugs.[3] (4) This represents the concentration of a substance required to inhibit a specific biological process, such as cell growth, by 50%, used to assess the potency of the extract.[4] (5) The concentration of a substance required to inhibit a biological process by 50%, which for Gallic Acid was determined to be 35 μM in this study.[5]