Significance of IC50
IC50 is defined as the half maximal inhibitory concentration, representing the concentration of a substance required to inhibit a specific biological process or cell growth by 50%. It serves as a vital measure of a drug's potency and is frequently utilized in cytotoxicity tests to evaluate the effectiveness of various compounds and treatments. This parameter is crucial in fields such as cancer research, where determining the IC50 can aid in assessing the efficacy of therapeutic agents against cancer cells or other biological targets.
Synonyms: Half-maximal inhibitory concentration, Ic50 value, Inhibition constant, Drug potency
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The concept of IC50 in scientific sources
IC50 is a crucial measure in cytotoxicity tests, indicating the concentration of a substance required to inhibit 50% of cell growth, thereby helping to evaluate the substance's effectiveness in research.
From: The Malaysian Journal of Medical Sciences
(1) This is the concentration of goniothalamin that causes a 50% reduction in cell viability, measured at different time points.[1] (2) This represents the concentration of a substance required to inhibit the growth of cells by 50%, used to assess the cytotoxic activity of the extracts.[2] (3) This is the half maximal inhibitory concentration, used to determine the effectiveness of a substance.[3] (4) IC50 refers to the half inhibitory concentration, and for the DPPH assay, the antioxidant activity was determined in terms of the IC50 value, and the IC50 for ORL115 and ORL188 were determined in this study.[4] (5) This is the half maximal inhibitory concentration, representing the concentration of a substance needed to inhibit a specific biological process by 50%.[5]