Significance of Human leukocyte antigen
Human leukocyte antigen is a system of genes crucial for the immune system's ability to recognize foreign substances. These proteins serve as markers on cell surfaces and are instrumental in differentiating self from non-self, which is vital in immune responses. Certain alleles within this system are linked to various health risks, including autoimmune diseases, periodontal disease, and severe reactions to medications like Carbamazepine. Additionally, HLA gene complexes are significant in assessing genetic predisposition to conditions such as multiple sclerosis and aggressive periodontitis.
Synonyms: Major histocompatibility complex (mhc), Tissue antigens, Mhc
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Human leukocyte antigen'
From: Journal of Ayurveda and Integrated Medical Sciences
(1) This refers to a specific genetic factor, HLA Cw6, associated with the skin condition, as described within the context of the text.[1]
From: International Research Journal of Ayurveda and Yoga
(1) This is a genetic factor, specifically HLA-B 27, that is situated at chromosome 6 and plays a very forceful role in ankylosing spondylitis, an autoimmune disease.[2]
The concept of Human leukocyte antigen in scientific sources
Human leukocyte antigen (HLA) is a gene complex essential for immune cell proteins, significantly impacting the immune response and its connection to diseases like multiple sclerosis. It influences how the body recognizes and responds to pathogens.
From: The Malaysian Journal of Medical Sciences
(1) This is a system of genes that helps the immune system recognize foreign substances, used in the past for identification.[3]
From: South African Family Practice
(1) This is a genetic component strongly associated with coeliac disease, with nearly all patients sharing the same genetic predisposition, and the presence of either HLA-DQ2 or HLA-DQ8 alleles is a key factor in the disease.[4]