Significance of Holoprosencephaly
Holoprosencephaly is a developmental disorder characterized by the brain's failure to divide into two hemispheres, which can lead to various brain malformations. This condition is often autosomal dominant and can manifest in oral features, such as the absence of the labial maxillary frenum.
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The concept of Holoprosencephaly in scientific sources
Holoprosencephaly is an autosomal dominant condition marked by brain malformation, specifically the failure of the forebrain to divide into two hemispheres, which can result in distinct oral features like the absence of the labial maxillary frenum.
From: World Journal of Pharmaceutical Research
(1) A developmental disorder whereby the forebrain fails to properly divide into two hemispheres.[1]
From: Journal of Indian Society of Periodontology
(1) An autosomal dominant condition characterized by brain malformation manifesting in oral features including the absence of the labial maxillary frenum.[2]