Significance of Hepatotoxicity
Hepatotoxicity refers to the condition of liver damage resulting from exposure to toxic substances, particularly medications, which can lead to severe health issues. This term encompasses various scenarios, including liver damage from anti-tuberculosis drugs, the alkaloid mixtures tested, and long-term use of certain herbal extracts or chemicals like carbon tetrachloride. Concern over hepatotoxicity arises due to its implications for liver function, indicated by elevated liver enzymes and other biochemical markers. Proper assessment is vital for identifying potential liver injury associated with different substances.
Synonyms: Liver toxicity, Liver damage, Hepatocellular injury, Hepatic toxicity
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Hepatotoxicity in scientific sources
Hepatotoxicity involves liver damage from chemicals, drugs, or toxins, indicated by elevated liver enzymes. It is particularly significant in medication side effects, such as with DOTS and long-term DMARD use, leading to various health complications.
From: World Journal of Pharmaceutical Research
(1) Damage to the liver observed in rats, supported by increased levels of liver enzymes ALT and AST in serum.[1] (2) The chemical-induced liver damage that can occur due to the ingestion of toxic substances.[2] (3) Liver toxicity associated with certain medications, including sulfadiazine, which can lead to severe side effects.[3] (4) The toxicity that can result from exposure to certain substances, including heavy metals and over-the-counter drugs, leading to liver injury.[4] (5) Potential toxicity to the liver caused by certain medicines, which may also impact kidney stone formation.[5]
From: Ancient Science of Life
(1) Liver damage or injury, specifically induced in this study by carbon tetrachloride and liquid paraffin.[6] (2) The potential of a substance to cause liver damage, a significant concern regarding the alkaloid mixture tested in the study.[7] (3) The condition of liver damage caused by toxic substances, such as carbon tetrachloride, leading to the leakage of liver marker enzymes into the bloodstream.[8] (4) Potential toxic effects of substances on the liver, which were investigated through various biochemical assays to ensure the safety of the extract.[9] (5) Chemical-driven liver damage, which in this study is induced by lead acetate.[10]
From: International Ayurvedic Medical Journal
(1) The occurrence of liver damage or dysfunction due to exposure to toxic substances, including certain drugs.[11] (2) Damage to the liver caused by toxins, medications, or other harmful agents, a significant concern discussed in relation to the effectiveness of Abhayadi Ghrita.[12] (3) Liver damage caused by exposure to toxic substances such as drugs, which can mimic liver diseases.[13] (4) The liver's susceptibility to damage from toxins, chemicals, or drugs, which can lead to serious liver diseases.[14] (5) Hepatotoxicity refers to liver toxicity, which was observed variably among the different samples of Rasakarpura, with R.K-4 exhibiting more toxicity.[15]
From: AYU (Journal of Research in Ayurveda)
(1) Liver damage due to toxic substances, noted as a concern with long-term use of Plumbago zeylanica extracts.[16] (2) A property of certain drugs that may cause damage to the liver, common in treatments for Alzheimer's dementia.[17] (3) Liver damage caused by medication, particularly relevant in the context of the side effects of DOTS.[18] (4) Long-term use of DMARDs can lead to adverse effects including marrow, renal, and hepatic suppression.[19]
From: Journal of Ayurveda and Integrative Medicine
(1) The potential of a substance to cause liver damage or affect liver function negatively.[20] (2) Liver damage caused by exposure to toxic substances, including certain drugs like Cisplatin.[21] (3) Cadmium (Cd) is recognized as a dangerous factor causing hepatotoxicity amongst other organ toxicities.[22] (4) The condition of liver damage induced by toxic substances, exemplified by the hepatotoxic effects observed after the administration of carbon tetrachloride in the experimental animals.[23]
From: Journal of Ayurveda and Holistic Medicine
(1) Liver damage caused by exposure to toxins such as carbon tetrachloride, which leads to increased levels of liver enzymes and other biochemical markers in the bloodstream.[24] (2) Liver damage caused by chemicals or drugs, which can result in conditions like hepatocellular jaundice.[25]
From: The Malaysian Journal of Medical Sciences
(1) Liver damage caused by certain dietary supplements, especially noted with products containing camellia sinensis (green tea).[26] (2) Liver toxicity that can occur with certain substances, including some components derived from plants.[27]