Significance of Genetic mutation
Genetic mutation, according to the provided text, refers to alterations in DNA sequences with diverse impacts. These changes can lead to various health conditions, including cancer, Parkinson's disease, and heart diseases, as well as affect drug responses and antibiotic resistance. Genetic mutations are also explored in relation to mental health conditions, such as schizophrenia. Furthermore, they can influence metabolic processes and are associated with diseases like Gaucher disease and Niemann-Pick disease. They can also affect the virulence of viruses like Ebola.
Synonyms: Genetic alteration, Genetic variation, Genetic change, Genetic modification, Gene alteration, Dna variation, Chromosomal mutation
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Genetic mutation'
In Hinduism, genetic mutations are DNA alterations causing issues like cancer. These mutations disrupt cell growth, affecting functions such as lipid metabolism. Germ-line mutations in genes like BRCA1/2, ATM, and p53 are linked to breast cancer.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Genetic mutations are alterations in the DNA sequence that can lead to changes in the body's functions, including lipid metabolism.[1] (2) These are alterations in the DNA that drive the uncontrolled cell growth that characterizes cancer, affecting key regulatory mechanisms in cellular processes.[2]
From: Journal of Ayurvedic and Herbal Medicine
(1) A cause of breast cancer that can arise from germ-line mutations in high-penetrance of BC with associated gene mutation including BRCA 1 and BRCA 2, and also in ATM and p53 genes.[3]
The concept of Genetic mutation in scientific sources
Genetic mutations involve alterations in DNA sequences that can cause various health issues. These include cancer, neurodegenerative diseases, genetic disorders like Gaucher disease, and conditions like Kindler's syndrome. They also play a role in antibiotic resistance, drug responses, and can increase the risk of diseases such as Alzheimer's and T2DM.
From: International Journal of Pharmacology
(1) From a microbiological perspective, drug resistance is caused by this, making a drug ineffective.[4] (2) Genetic mutations are a consequence of factors like smoking and alcohol consumption, contributing to the development of Laryngeal squamous cell carcinoma.[5] (3) Alterations in the DNA sequence of C. auris that are considered the most likely contributing factors to its unexpected growth in the presence of atorvastatin.[6] (4) Alterations in DNA sequences, such as those in BRCA1 and BRCA2 genes, that can significantly increase the risk of developing certain cancers like breast cancer.[7] (5) These, like NKX2-5 and GATA4, are commonly associated with atrial septal defects.[8]
From: The Malaysian Journal of Medical Sciences
(1) A change in the DNA sequence of genes, in this study specifically relating to the p53 and p27 genes detected in the tumor.[9]
From: Journal of Public Health in Africa
(1) Genetic mutations are alterations within genes, particularly BRCA 1 and BRCA 2, that increase the risk of developing breast cancer in individuals.[10]
From: South African Family Practice
(1) This is a change in the genetic material that can increase susceptibility to ototoxicity, making individuals more vulnerable to hearing loss from certain drugs.[11]
From: Journal of Metabolic Health
(1) The explosion of knowledge in genetics led to the discovery of diseases resulting from single genetic mutations, which contrasts with the multifactorial nature of modern chronic illnesses.[12]
From: South African Journal of HIV Medicine
(1) Genetic mutations of HIV are a factor in treatment, and stavudine and zidovudine could be used in a similar fashion to drugs that have different toxicity profiles.[13]
From: Onderstepoort Journal of Veterinary Research
(1) These play a major role in the development of Campylobacter resistance, especially concerning fluoroquinolones, and the document explains how specific changes affect the bacteria's resistance.[14]
From: African Journal of Primary Health Care and Family Medicine
(1) These are changes in genes that can increase the risk of cancer, and their role is investigated, particularly in the context of breast and ovarian cancers, due to inherited variations.[15]
From: Asian Journal of Pharmaceutics
(1) Alterations in an individual's DNA that can be identified through genomic data, influencing health and treatment strategies.[16]
From: South African Journal of Psychiatry
(1) These alterations are explored in the context of schizophrenia, particularly their role in the development of the condition.[17] (2) These have been identified in patients with certain types of periventricular nodular heterotopia, and indeed other forms of grey matter heterotopia.[18]
From: International Journal of Pharmacology
(1) Alterations in the DNA sequence of genes, which can affect the function of transporters and influence drug responses.[19] (2) Accumulations of these in immunoglobulins produced by mutant plasma cells have been reported as hereditary causes contributing to familial multiple myeloma.[20]