Significance of Fusion protein
Fusion protein is a critical component in various biological contexts, particularly in virology and diagnostics. It serves as an important determinant of pathogenicity in viruses such as Newcastle Disease Virus, where its nucleotide sequence aids in phylogenetic analysis. Fusion proteins are essential for viral infection by facilitating the fusion with host cells, requiring cleavage into functional peptides. Additionally, they play roles in serological diagnostics for diseases like leptospirosis and are utilized in engineered proteins for research and therapeutic applications.
Synonyms: Chimeric protein, Recombinant protein
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The concept of Fusion protein in scientific sources
Fusion protein, vital for serological diagnosis, pathogenicity, and viral fusion, plays a significant role in analyzing diseases like leptospirosis and Newcastle disease. Its character is essential for understanding viral virulence and genetic differentiation.
From: Onderstepoort Journal of Veterinary Research
(1) This is a protein found in APMV-1, and the analysis of its cleavage site is crucial for determining the virulence and genetic characteristics of the virus strains present.[1] (2) The fusion protein is a protein that is synthesized as a precursor, and it is essential for the virus to fuse with and infect host cells, and this precursor must be proteolytically cleaved to form F1 and F2 peptides for fusion activity to occur.[2] (3) This is one of the eight proteins encoded by the PPR virus genome, represented by the letter F.[3] (4) The fusion protein gene was targeted in a one-step RT-PCR to analyze the genetic material, and the amino acid sequence of the fusion protein was also analyzed.[4] (5) The fusion (F) protein is an important determinant of pathogenicity of the virus and is used commonly for phylogenetic analysis Newcastle disease viruses from various geographical regions, and analysis of the nucleotide sequence data from the F gene, encoding for the fusion protein of NDV, has allowed differentiation of closely related viruses.[5]
From: The Malaysian Journal of Medical Sciences
(1) A specific protein, such as the NanoLuc Luciferase, is engineered to be expressed as a fusion protein for MNV-1 minor capsid protein, VP2.[6] (2) Fusion protein is a protein that is used in the serological diagnosis of human leptospirosis, specifically rLipL32/1-LipL21-OmpL1/2.[7] (3) The Acr protein linked to an N-terminal His tag, used to facilitate purification in the experiment.[8]
From: South African Family Practice
(1) These are another type of biological DMARDs, designed to bind and inactivate immune targets, often used in combination with other treatments like methotrexate.[9]
From: Asian Journal of Pharmaceutics
(1) A protein that facilitates the merging of membranes, and is cleaved by Cathepsin L in the severe acute respiratory syndrome coronavirus.[10]
From: International Journal of Pharmacology
(1) Expression of CPP-cargo as this in E. coli or Saccharomyces cerevisiae.[11]
From: International Journal of Pharmacology
(1) A fusion protein involving the B subunit of Escherichia coli heat-labile enterotoxin was expressed in transgenic tomato, indicating a strategy for vaccine development.[12]