Significance of Elevated plus maze test
Elevated plus maze test: This behavioral test is primarily used to evaluate anxiety levels in rodents. Researchers observe the animal's willingness to explore open versus closed arms of an elevated maze. The test also assesses learning and memory. By measuring the rodent's preference for open or closed spaces, scientists can gauge anxiety-related behaviors and evaluate the effects of anxiolytic drugs. It creates a conflict between the animal's desire to explore and its fear of open, unprotected areas.
Synonyms: Epm, Elevated plus maze, Anxiety test, Anxiety assessment, Behavioral test
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The concept of Elevated plus maze test in scientific sources
The Elevated plus maze test is a behavioral assay used to evaluate anxiety in rodents. It measures their willingness to explore open versus closed arms of a maze, assessing anxiety-related behavior.
From: International Journal of Pharmacology
(1) The elevated plus-maze test is the most frequently used model for assessment of the anxiolytic activity of a new substance, including herbal remedies, in rodents when assessing the anxiolytic activity of Galphimine-A.[1] (2) Using it, the reduction in Transfer Latency on acquisition and retention were considered as an improvement in animals learning capability.[2] (3) Average number of entries in open arm was 2.66 and time spent on open arm was 11.5 sec in the vehicle treated control group.[3]
From: Asian Journal of Pharmaceutics
(1) In this test, the entry and spend time in the open arms were significantly decreased in LPS-exposed mice.[4]
From: The Malaysian Journal of Medical Sciences
(1) Behavioral tests used to measure anxiety in rodents based on their willingness to explore open versus closed arms.[5] (2) A behavioral test designed to assess anxiety levels in animals based on their exploration of open versus closed arms.[6]