Significance of Dose-dependent effect
A dose-dependent effect refers to the relationship where the magnitude of a response increases with the dosage of a substance administered. This concept is illustrated in various studies, such as the hepatoprotective activity of Gracilaria corticata, the bronchodilator effects of E. hirta, and the impact of amlodipine on cognitive impairment. The principle demonstrates that higher doses typically lead to more significant effects, seen in various contexts like analgesic efficacy, cytotoxicity, and neurotoxicity, highlighting the importance of dosage in pharmacological outcomes.
Synonyms: Dose-response relationship, Concentration-dependent effect, Dose-related effect, Concentration effect
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The concept of Dose-dependent effect in scientific sources
The dose-dependent effect describes how the impact of Argemone mexicana leaf extract on MCF-7 cells intensifies as the concentration of the extract increases, indicating a direct relationship between dosage and cellular response.
From: The Malaysian Journal of Medical Sciences
(1) This means that the impact of the treatment is determined by the amount administered, indicating that the treatment's effect on the mother's weight was related to the extract dosage.[1] (2) This indicates that the impact of a substance on bone health is influenced by the amount administered, with different dosages producing varying results, which can be assessed.[2] (3) The relationship between the amount of treatment administered and the magnitude of its effect observed in the study.[3] (4) The observation that the therapeutic effects and potential neurotoxic effects of minocycline vary based on the concentration administered.[4] (5) The relationship between the amount of the extract administered and its resulting effects on blood glucose levels and tissue health in rats.[5]