Significance of Dose-dependent
Dose-dependent, as it relates to health sciences, signifies a relationship where the effect of a substance varies proportionally with the amount administered. This concept is illustrated through numerous examples, including antioxidant and anti-inflammatory activities, where responses change with varying concentrations. It also describes how a treatment's effects, such as antibacterial or antifungal activity, increase with higher concentrations, or how morphological changes and insulin secretion relate to administered doses. Essentially, dose-dependent indicates that the intensity of an effect correlates directly with the amount of a substance given.
Synonyms: Dosage-dependent, Concentration-dependent
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Dose-dependent'
In Hinduism, dose-dependent signifies how a substance's impact correlates with its concentration or dosage. This is seen in examples like extract scavenging activity, the effects of Nagapashana Pishti, and the analgesic activity of extracts.
From: Journal of Ayurvedic and Herbal Medicine
(1) This refers to the relationship where the effect of a substance, like the scavenging ability of a drug, changes proportionally with the concentration or dosage of the substance.[1] (2) This refers to a relationship where the effect of a substance is related to the amount or concentration of the substance, with greater effects at higher doses.[2] (3) This describes how the methanolic leaf extract reduced the elevated body temperature, with the effect increasing as the dose increased.[3] (4) The effect of the extract, where the scavenging activity increased with the concentration of the extract, as observed in the hydrogen peroxide assay.[4]
From: Journal of Ayurveda and Integrated Medical Sciences
(1) This indicates that the analgesic activity of the extracts increased or decreased in relation to the amount administered.[5] (2) This describes the manner in which the effects of Nagapashana Pishti varied with the dosage administered, as noted in the text.[6] (3) This is a relationship where the effect of a substance is related to the amount given, which was observed in studies of Callicarpa macrophylla.[7]
The concept of Dose-dependent in scientific sources
"Dose-dependent" describes a relationship where the effect of a substance changes with the amount administered. This is observed across various contexts, including insulin secretion, gastric damage, drug effects, and treatment efficacy. The effect can increase, decrease, or vary in intensity proportionally to the dosage.
From: International Journal of Pharmacology
(1) Mice that received different doses of G-A presented a significant increment in the percentage of Entries on Open Arms and percentage of time spent on open arms in the EPM test, and this effect was dose-dependent.[8] (2) Dose-dependent describes the relationship where the effect of a substance, like favipiravir, increases or decreases in proportion to the amount of the substance administered to the rats.[9] (3) The study provides evidence of the dose- and time-dependent neurotoxic and memory-impairing effects of ketamine.[10] (4) The modulation of the Th1 response by Bifidobacterium indicates a more dynamically regulated immune response that could prevent overactivation and tissue damage.[11] (5) The effect of Calein D was this, reaching its maximum antinociceptive effect at the highest dose of 56 mg/kg.[12]
From: The Malaysian Journal of Medical Sciences
(1) A relationship where the effect of a substance varies with the amount administered, which was observed in the extracts' inhibitory effects.[13] (2) This means that the effect of the treatment varies based on the amount given, suggesting that the intensity of the effect on the mother's weight depended on the dosage of the extract.[14] (3) A relationship where the risk of adverse outcomes increases with the number of packed red blood cell transfusions, which was observed in the study for several post-operative adverse events.[15] (4) This term refers to the relationship between the amount of a substance and its effect, and the study tested this relationship for the honey's inhibition activity.[16] (5) This describes how the TFC content of the extracts changes, as well as the cytotoxicity observed in the study.[17]
From: Asian Journal of Pharmaceutics
(1) It refers to the effect of a drug, such as Detralex, where the magnitude of the effect is related to the dosage of the drug administered.[18] (2) The side effects of Stavudine are this and a reduction of the total administered dose reduces the severity of the toxicity.[19] (3) This means that the effect does not increase proportionally with the amount of the substance administered.[20] (4) The effect of a substance that increases with increasing concentration.[21] (5) CO treatment 2 at 200 mg/kg bw in Group D was more effective as compared to treatment 1 at 100 mg/kg bw, indicating the effect was dose dependent.[22]
From: Journal of Medicinal Plants for Economic Development
(1) The relationship between the amount of Jatropha gossypifolia extract administered and its effect on reducing the frequency of micronucleated polychromatic erythrocytes.[23] (2) This is a pattern of the effect of the extract, which increases with the dose given to the mice.[24] (3) This describes a relationship where the effect of a substance changes depending on the amount administered, either increasing or decreasing with dosage.[25]
From: African Journal of Primary Health Care and Family Medicine
(1) This term is used to describe the effects of calcium channel blockers, gabapentin, and pregabalin, which can cause oedema.[26] (2) This describes the relationship between the amount of medication administered and the effect it has on the body, which is a crucial consideration in treatment.[27]
From: South African Family Practice
(1) The effects of intrathecal morphine, particularly the risk of respiratory depression, are dose-dependent, meaning that higher doses are associated with a greater likelihood of adverse events.[28] (2) In all cases, GI effects are this and combinations are associated with greater risks, as stated in the text.[29]
From: Onderstepoort Journal of Veterinary Research
(1) The study's results indicate that the morphological changes caused by carbendazim are dose-dependent, with varying effects observed at different concentrations.[30] (2) This describes the relationship between the amount of methylparaben exposure and the severity of the observed effects, such as weight loss and tissue damage, in the study.[31]
From: South African Journal of HIV Medicine
(1) This refers to the relationship between the amount of stavudine used and the likelihood of associated toxicities.[32]
From: International Journal of Pharmacology
(1) Describes a relationship where the effect of a substance varies directly with its dosage.[33] (2) The effect of a substance varies according to the amount administered, as seen with the cell growth inhibition by parameritannins.[34] (3) Describes the relationship where the effect of a substance increases proportionally with the dose or concentration administered.[35] (4) The extent of histological injury to rat organs caused by gold nanoparticles is directly related to the amount administered.[36] (5) The observed reduction in total cholesterol, triglycerides, LDL-, VLDL-cholesterol, and increase in HDL-cholesterol was dose dependent, meaning it varied with the administered dose of EEPM.[37]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Dose dependent refers to the relationship between the amount of a substance (e.g., medication) administered and the effect it has, where higher doses may lead to increased effects or side effects.[38] (2) The effect of Juvenile Hormone Analogues on the silkworm Bombyx mori is dose-dependent, influencing the enhancement of certain enzyme activities in the silkworm.[39] (3) The direction of the modifying effect of concomitant toluene exposure on benzene's metabolism is dose-dependent, indicating that the extent of the effect is related to the amount of toluene exposure.[40] (4) The term "dose dependent" indicates that the observed effects or responses are related to the amount of substance administered, with higher doses typically leading to greater effects.[41] (5) A relationship where the effect of a substance on an organism or cell increases as the amount of exposure to the substance increases.[42]
From: International Journal of Pharmacology
(1) This describes the effect of the ethanol extract of Zingiber zerumbet, where the anti-pyretic activity increased with the concentration.[43] (2) This is a description of the effect of the root extract, indicating that the intensity of its analgesic and anti-inflammatory effects increased with the amount of the extract administered.[44]
From: South African Journal of Psychiatry
(1) The teratogenic effect of sodium valproate is dose-dependent, meaning that the risk of abnormalities increases with higher doses of the medication.[45] (2) This describes how the tendency of antipsychotics to elevate plasma prolactin levels is affected by the amount of medication taken, with higher doses more likely to cause a rise.[46] (3) The relationship where the effects of a medication, such as the risk of foetal valproate syndrome, are related to the amount of the drug administered.[47] (4) This describes the risk of seizures associated with clozapine, which was found to increase as the dosage of the medication was increased.[48]