Significance of Dose-dependent
Dose-dependent refers to the characteristic of a substance where its effects, such as antibacterial, analgesic, or antifungal properties, increase with the concentration or amount administered. This concept is crucial for understanding how the efficacy of various extracts and drugs, like Lannea microcarpa, Celosia argentea, and Nigella sativa, varies in relation to dosages. Observing a dose-dependent response helps in determining the optimal dosage for achieving desired therapeutic effects while minimizing adverse reactions.
Synonyms: Dosage-dependent, Concentration-dependent
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Dose-dependent in scientific sources
Dose-dependent signifies that the effectiveness of a treatment correlates with the administered amount, as seen in S. jambos extract, reflecting how responses to drugs or substances change in relation to dosage increases.
From: World Journal of Pharmaceutical Research
(1) A response that varies according to the amount of substance administered.[1] (2) The relationship in which the effect observed increases with the amount of the extract or drug administered, noted in the study's findings.[2] (3) The relationship between the amount of a substance administered and the resulting effect, typically indicating that higher doses produce greater effects.[3] (4) Referring to the relationship where the effects of MHB-21 increase with the increase in dose administered to the mice.[4] (5) A term indicating that the effects of the decoction of Coccinia grandis L vary according to the quantity administered.[5]
From: Ancient Science of Life
(1) Referring to the relationship between the dose of A. indica leaf extract and the resulting hepatoprotective activity observed in the study.[6] (2) A term indicating that the effect of a drug increases with higher dosages, observed with TBR-002 and other antipyretics in reducing pyrexia.[7] (3) The effect of a substance that increases with the amount administered.[8] (4) Referring to the effect of a treatment that varies according to the amount administered, noted in the anti-ulcer activity.[9] (5) The characteristic that an effect or response is directly proportional to the amount of drug administered, observed in the effects of the herbal extract.[10]
From: AYU (Journal of Research in Ayurveda)
(1) Describing the relationship where the effects of CTE increased with higher doses administered to the subjects.[11] (2) Describes the relationship where the effect or response to a drug changes with the amount administered.[12] (3) The response to a treatment correlates with the amount administered; in this study, the effectiveness of S. jambos extract was dose-dependent.[13] (4) Describes a relationship where the effect of a substance, such as ghee on serum lipids, increases with the dose administered.[14]
From: International Ayurvedic Medical Journal
(1) A characteristic where the effects of a drug or treatment correlate directly with the amount administered.[15] (2) A relationship in the study indicating how the effects of the extract vary with different dosage levels (100, 200, 400 mg/kg).[16] (3) Indicating that the effects of Kshara can vary based on the amount administered, relevant in its applications.[17]
From: The Malaysian Journal of Medical Sciences
(1) Describing a response (e.g., therapeutic effects) that varies according to the amount of substance administered.[18] (2) The relationship where the effect of a treatment increases with the amount administered.[19]
From: Journal of Ayurveda and Integrative Medicine
(1) Refers to the relationship between the amount of a treatment given and its effects, important for determining the efficacy of Litsea glutinosa.[20] (2) The relationship indicating that the effects of the extracts on gastric damage increased with varying doses administered to the rats.[21]