Significance of Dose
The term "dose" refers to the specific quantity of a substance administered in various contexts. In Ayurveda and Rasashastra, it's the amount of medicine given, measured in units like rakti or grams, crucial for therapeutic effects. In Science, dose relates to the quantity of radiation or decoction used in experiments. Health Sciences defines dose as the amount of medication given, whether for humans or animals, and emphasizes its importance in achieving desired outcomes and avoiding adverse effects. The text highlights the variability of doses depending on the substance, the patient's condition, and the treatment's goals.
Synonyms: Dosage, Amount, Measure, Portion, Quantity, Allocation, Administration
In Spanish: Dosis; In Finnish: Annos
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Buddhist concept of 'Dose'
In Buddhism, "Dose" signifies hate or aversion. This defilement, linked to greed, fuels suffering and negative mental states, representing a significant obstacle on the path to enlightenment.
Hindu concept of 'Dose'
In Hinduism, "Dose" signifies the precise quantity of medicinal substances and treatments. It encompasses the amount of various compounds, herbal preparations, and mixtures, like powders, oils, and eye drops, to be administered for therapeutic purposes. Dosage is carefully measured and adjusted based on factors like individual capacity, age, and the specific condition being treated.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Dose refers to the quantity of medicine administered, and for Amrutham Ghrita, a general dose of Uttama Matra (around 48 ml) can be considered in the absence of specific classical guidelines.[2] (2) This of Haridra is 1-3 gm of the drug in powder form.[3] (3) This is a part of the treatment.[4] (4) This is the amount of Panchashara Rasa, which is 1 Valla Pramana and is indicated in Klaibya.[5] (5) This refers to the specific amount of a Pottali preparation to be administered, varying based on the type and its ingredients.[6]
From: International Research Journal of Ayurveda and Yoga
(1) The amount of medication to be administered at one time, which varies among the types of Sameer Pannaga Rasa.[7] (2) Rudantyadi Yog 1 gm TDS (3 gm/day) with luke warm water. Mamajjak Ghan Vati 1 gm TDS (3 gm/day) with luke warm water.[8] (3) The dose of Hingwashtaka Churna is 1 to 2 g as per Ayurvedic Formulary of India.[9] (4) Dose refers to the amount of Narikela Khanda or Kushmanda Khanda, which is 10 gm twice daily after food for 30 days.[10] (5) This word specifies the amount of Jatamansi Churna given to patients, as detailed in the methodology, which was 5 grams twice daily, clarifying the treatment dosage.[11]
From: Journal of Ayurvedic and Herbal Medicine
(1) The study specifies the dose of the treatments: two drops of either Nimbadi eye drops or Levofloxacin 0.5% ophthalmic solution, administered four times a day for ten days, as mentioned in the methods.[12] (2) The dose of the eye drops administered was 1 drop in each eye, as a part of the intervention, as explained in the materials and methods section.[13] (3) This refers to the proper quantity of a drug recommended by a physician to a patient in a particular condition, and is crucial in herbo-mineral preparations because of their high potency.[14]
From: Rasa Jala Nidhi, vol 4: Iatrochemistry
(1) The dose for the final product is specified as eight raktis for each application.[15] (2) The dose of this medicine should be carefully determined based on the patient's age and overall physical condition.[16] (3) A dose of six raktis of the powdered medicine is to be taken with honey for therapeutic effect.[17] (4) The recommended amount is one rakti in weight for administration.[18] (5) The prescribed amount, three raktis each, of the dried preparation taken with sugar and tanduliyaka juice or sugar alone.[19]
From: Kautilya Arthashastra
(1) The proportion of a remedy, measured in aksha, varies for men, cows, horses, elephants, and camels.[20]
From: Vakyapadiya of Bhartrihari
(1) A dose refers to a specific quantity, such as the amount of medicated oil consumed in the example 'tailam bhuktam', representing a part of the total available oil.[21]
The concept of Dose in scientific sources
"Dose" signifies the specific quantity of a substance administered, varying widely depending on the context. It encompasses the amount of drugs, radiation, or extracts given to humans, animals, or cells, influencing treatment efficacy and potential side effects. Dosage can be measured in different units, like grams or mg/kg.
From: International Journal of Pharmacology
(1) The oral low dose is not sufficient to decrease fluid overload and oral high dose had worsened outcomes because have more adverse effects.[22] (2) The text indicates that varying quantities can affect the levels of antibodies produced.[23] (3) Doses refer to the specific amounts of a substance administered to an organism in a study.[24]
From: Asian Journal of Pharmaceutics
(1) Nanosuspensions of pure drug offer a method to formulate poorly soluble drug and enhance the bioavailability of several drugs, this increases the bioavailability leading to a decrease in this.[25] (2) The real fact holding the truth behind it is that it can be administered as a multiple unit one.[26] (3) Along with ADRs, these were the most commonly asked DI questions.[27]
From: African Journal of Primary Health Care and Family Medicine
(1) These are the specific amounts of medication given to patients, and the text highlights the importance of accurate dosing, especially in children.[28]
From: Onderstepoort Journal of Veterinary Research
(1) Dose refers to the amount of ivermectin administered to the goats in the treatment group, which was 200 μg/kg body weight subcutaneously.[29] (2) This is the amount of medication given to an animal at one time, and the study used specific doses of ivermectin and albendazole.[30] (3) Dose is the amount of a substance administered to an organism, and the study used different doses of diclofenac to determine the LD50.[31]
From: South African Journal of HIV Medicine
(1) These do not need to be taken at precisely the same time each day, and patients should be told simply to take them once they remember to do so.[32] (2) This is the amount of medication given, and for amphotericin B, it is calculated based on the patient's weight and administered once daily.[33] (3) Dose is the amount of a drug to be taken, and the article discusses the dose of stavudine.[34]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) The amount of radiation absorbed by an organism, which can be estimated from the activity concentration of radionuclides in consumed food and the ingestion rate.[35] (2) The amount or duration of the intervention administered to participants, which is carefully determined and adjusted based on safety data.[36] (3) The dose of methadone is a critical factor, and specific parameters related to dose reduction during the tapering phase were found to be significantly associated with heroin abstinence.[37]
From: Sustainability Journal (MDPI)
(1) The dose of vine shoot activated carbon is an input variable that, when not considered in isolation, significantly impacts abiotic depletion (Ab_depl) and several other environmental metrics.[38] (2) Dose, along with concentration and time, are parameters used in experiments for Cr +6 removal (%) using CC, GCC, NC, and NGC.[39] (3) The amount of a substance to which a person is exposed, influencing the potential for adverse health effects.[40]
From: International Journal of Pharmacology
(1) Doses of the decoction tested ranged from 17.1, 42.7, 85.5, to 171 mg kg -1, administered intraperitoneally one hour before the tests.[41] (2) The dose of radiation administered from 131I is a critical factor, and while it can be standardized, reducing the dosage has not led to long-term improvements in treatment outcomes.[42]
From: South African Journal of Psychiatry
(1) This refers to the amount of medication administered to a patient, particularly in the context of antipsychotics and the concept of high doses.[43]