Significance of Dissolution test
The dissolution test is a laboratory procedure designed to measure the rate and extent at which a drug is released from its dosage form into a specified fluid medium, such as 0.1 N HCl or PBS at varying pH levels. This evaluation is crucial for assessing the bioavailability and therapeutic effectiveness of medications, as it reflects how quickly and efficiently active ingredients dissolve, impacting their absorption and performance in the body.
Synonyms: Dissolution assay, Solubility test, Release test
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The concept of Dissolution test in scientific sources
The Dissolution test is a laboratory procedure that assesses the release rate and effectiveness of drugs, particularly for 5-FU in suppository formulations, by measuring how quickly active ingredients dissolve in a specific medium.
From: World Journal of Pharmaceutical Research
(1) A test to evaluate the dissolution characteristics of orally disintegrating tablets (ODTs) under specific conditions comparable to conventional tablets.[1] (2) A laboratory procedure used to assess how quickly and efficiently the active ingredient in a drug is released in solution.[2] (3) A procedure used to determine how quickly an active ingredient is released from its tablet form into a solution.[3] (4) Performed to assess the release of drugs from tablets using specific media such as 0.1 N HCl and PBS at different pH values.[4] (5) Tests conducted to determine how long it takes for a drug to release from a dosage form in a fluid medium.[5]