Significance of Dissolution rate
Dissolution rate is a crucial measure that indicates how quickly a drug dissolves in a solvent, significantly affecting its bioavailability and therapeutic effectiveness. This metric is vital for assessing the performance of various dosage forms, including solid formulations like tablets. A faster dissolution rate promotes better absorption and efficacy of the drug. Thus, understanding the dissolution rate is essential for optimizing drug formulations, particularly for poorly soluble medications, to enhance their bioavailability and ensure effective therapeutic action.
Synonyms: Dissolution velocity, Release rate, Dissolution speed
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The concept of Dissolution rate in scientific sources
Dissolution rate is crucial in pharmacology, indicating how quickly a drug dissolves in a medium, affecting its absorption and action onset. It is improved in solid dispersions and influenced by the drug's particle size.
From: World Journal of Pharmaceutical Research
(1) The speed at which a drug dissolves in a solution, crucial for determining the drug’s absorption rate in the body.[1] (2) The speed at which a solid drug dissolves in a liquid medium, impacting its absorption in the body.[2] (3) The speed at which a solid drug dissolves in a solvent, influencing bioavailability and therapeutic effectiveness.[3] (4) The speed at which a drug is released from its dosage form into solution, influencing the onset of action and overall bioavailability.[4] (5) The rate at which a drug dissolves in a solvent, which has implications for its absorption and bioavailability.[5]
From: International Ayurvedic Medical Journal
(1) The speed at which a drug dissolves in a solvent, influenced by the particle size of the powdered form.[6]