Significance of Disintegration time
Disintegration time is defined as the duration required for a tablet to break down into smaller particles in a specific fluid medium. This measure is critical in assessing a tablet's effectiveness, as it influences the drug's release rate and absorption after administration. Disintegration time varies by formulation and can be essential for fast-dissolving oral dosages, impacting how quickly a drug becomes available in the body. Understanding this parameter helps ensure optimal performance and efficacy of pharmaceutical products.
Synonyms: Dissolution time, Decay time
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Disintegration time in scientific sources
Disintegration time measures how long a tablet takes to break down, influencing product quality and absorption. For example, Mehamudgara vati disintegrates in 17 minutes, impacting the efficacy of various herbal tablets like LMV Rasa and Jivanti Ghana.
From: World Journal of Pharmaceutical Research
(1) The duration taken for a tablet to break down into smaller particles, either in vitro (in a controlled environment) or in vivo (within a living organism).[1] (2) The time taken for a tablet to break apart in a solution, which affects the dissolution rate of the drug.[2] (3) The period required for a tablet to break down into smaller particles when tested in specified fluids.[3] (4) The period during which a tablet breaks down into smaller particles, crucial for determining how quickly it will dissolve in the mouth.[4] (5) The duration required for a tablet to break down into smaller fragments in a liquid environment.[5]
From: International Ayurvedic Medical Journal
(1) The period required for a tablet to break down into smaller fragments in the gastrointestinal tract after ingestion.[6] (2) The time it takes for Sanjivani Vati to break into smaller fragments in the gastrointestinal tract after ingestion.[7] (3) The time required for a tablet to break into particles in a specific media, essential for assessing the therapeutic utility of solid dosage forms.[8] (4) The time required for a suppository to break down in liquid, indicating its release rate of active ingredients.[9] (5) The duration it takes for a formulated pill (Sheetamshu Rasa) to break down in a solution, indicative of its physical properties.[10]
From: Ancient Science of Life
(1) Time required for a tablet to break down into smaller particles after exposure to a solvent, crucial for evaluating tablet performance.[11] (2) The duration it takes for a pharmaceutical preparation, such as a tablet or pill, to break down in the gastrointestinal tract.[12] (3) The duration taken for a tablet or pill to break down in a liquid medium, crucial for ensuring proper absorption.[13] (4) The time required for a tablet to break down into smaller particles after ingestion, measured in this study as part of the quality control parameters.[14]
From: AYU (Journal of Research in Ayurveda)
(1) The time required for a tablet to break down into smaller particles in a liquid environment, which affects how it is absorbed in the body.[15] (2) The time taken for the LMV Rasa tablets to break down in a specific environment, indicating the quality of the final product.[16] (3) The duration required for the Jivanti Ghana tablet to break down in solution, crucial for absorption.[17] (4) A measure of how long a tablet takes to break down; for Mehamudgara vati, it was recorded as 17 minutes.[18]
From: Journal of Ayurveda and Integrative Medicine
(1) Disintegration time is the duration required for the pill to break down into smaller particles in a liquid medium.[19] (2) The time taken for a tablet to break down into smaller particles in a specified fluid, crucial for determining the release of active ingredients.[20]