Significance of Disintegration time
Disintegration time is a crucial standardization parameter used in both Ayurveda and Science to evaluate the quality of pharmaceutical preparations like tablets. It refers to the duration it takes for a tablet to break down and dissolve in a specific medium, which is essential for releasing the active ingredients and ensuring effective drug absorption. Accurate measurement of disintegration time helps determine the efficiency of formulations, influencing their effectiveness and onset of action after administration.
Synonyms: Breakdown time, Decomposition time, Dissolution time, Decay time
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Disintegration time'
Disintegration time in Hinduism pertains to the duration required for medicinal tablets to dissolve, crucial for drug efficacy and absorption. It is measured using specialized apparatus, ensuring the quality and bioavailability of herbal formulations.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) This is a parameter, which is measured in two different solutions, providing information about the time it takes for the product to break down.[1] (2) This is a critical parameter for tablets, referring to the duration it takes for a tablet to break down and dissolve, which is crucial for drug release.[2] (3) This is one of the standardization parameters used to assess the quality of Pottali Kalpana, and is important.[3] (4) This is a measurement of how long it takes for a tablet to break apart and dissolve, releasing its ingredients. The prepared Haridra Khanda tablets were tested to ensure they met the required disintegration time, which is an important factor for the drug's effectiveness.[4] (5) This refers to the time it takes for a tablet to break down in a liquid, and the disintegration time of the Kaidaryadi Ghanavati tablets was measured to assess their bioavailability.[5]
From: International Research Journal of Ayurveda and Yoga
(1) This is one of the parameters that is used to assess the analytical profile of Angamardprashman vati and Bhagottar Gutika.[6] (2) This measures the time it takes for the medicine to break apart, affecting its absorption.[7]
The concept of Disintegration time in scientific sources
Disintegration time refers to the duration necessary for a tablet or film to break down into smaller particles in a specific medium, significantly impacting drug release and absorption efficiency after administration.
From: Asian Journal of Pharmaceutics
(1) It is the time it takes for a tablet to break apart in a fluid medium.[8] (2) One of the parameters for which the various tablet formulations are evaluated.[9] (3) For formulation F 8 this was (3.98 ± 0.15).[10] (4) The time it takes for a solid dosage form to break apart into smaller particles, an important factor in drug release.[11] (5) It is one of the properties, along with weight uniformity, %friability, and content uniformity, used to evaluate the formulated dispersible tablets.[12]
From: International Journal of Pharmacology
(1) The tablets were evaluated for content uniformity, hardness, friability, this and dissolution study, and it increased with increase in binder concentration.[13] (2) The FDTs which contained Ac-Di-Sol ® (i.e., FT-3 and FT-7) indicated the longest periods compared with WT and this[14]
From: Journal of Medicinal Plants for Economic Development
(1) Disintegration times are measured to determine how long it takes for a tablet to break apart in a liquid, which is an important factor in drug release.[15]
From: Sustainability Journal (MDPI)
(1) Disintegration Time is a measure in seconds, and the data shows the time it takes for soil samples to disintegrate under specific conditions, offering insights into soil stability.[16] (2) It is the duration it takes for soil to break apart, and this increases in reshaped red clay with an increase in clay content, according to the analysis results.[17]