Significance of Cytotoxicity assay
Cytotoxicity assay is a laboratory test used to evaluate the toxic effects of various substances on cell viability, often focusing on cancer cell lines. This method measures how treatments or extracts impact cell survival and proliferation, indicating their potential use in cancer therapy. Various specific applications of cytotoxicity assays include assessing the effects of isolated compounds, nanoparticles, and plant extracts on different cell lines, examining their safety and efficacy in medical research.
Synonyms: Cell viability assay, Toxicity testing, Cytotoxicity testing, Cell death assay
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Cytotoxicity assay in scientific sources
Cytotoxicity assay evaluates the toxicity of substances, such as plant extracts, on living cells. It determines the antiviral activity of extracts while assessing their harmful effects, exemplified by the chloroform extract of Portulaca oleracea and its impact on promastigotes.
From: World Journal of Pharmaceutical Research
(1) A laboratory test used to measure the toxicity of a compound on cells, particularly to evaluate its potential adverse effects.[1] (2) A biological test used to assess the toxic effects of substances, particularly drugs, on cultured cells, indicating their potential efficacy against cancer.[2] (3) An experimental procedure to assess the toxicity of a substance to cells, determining the non-toxic concentration for further testing.[3] (4) A method to evaluate the impact of substances on cell viability, specifically used to measure the anticancer properties of treatments.[4] (5) A test to assess the toxicity of substances on living cells.[5]
From: Journal of Ayurveda and Integrative Medicine
(1) Laboratory tests designed to determine the potential of a compound to kill or suppress the growth of cells, especially in cancer research.[6] (2) Tests performed to evaluate the toxic effects of compounds on cell viability.[7] (3) An experimental procedure used to determine the toxic effects of a substance on cell survival, typically measured through LDH release.[8] (4) Experiments conducted to evaluate the toxic effects of substances on cell viability, particularly in cancer cells.[9] (5) A test to evaluate the toxicity of a substance to cells, particularly used here to compare the effects of detoxified and non-detoxified extracts.[10]
From: The Malaysian Journal of Medical Sciences
(1) A method to determine the toxic effects of the extracts on human cell lines, ensuring that while acting against malaria, the extracts remain non-toxic to human cells.[11] (2) An experimental procedure to determine the toxicity of a substance by assessing its effects on living cells.[12] (3) Tests conducted to evaluate the toxic effects of substances on living cells, particularly their effects on cell viability.[13] (4) A type of evaluation performed to determine the cytotoxic effects of compounds or extracts on cell lines.[14]
From: AYU (Journal of Research in Ayurveda)
(1) A test conducted on extracts to assess their harmful effects on promastigotes.[15] (2) A test used to determine if the antiviral activity of plant extracts is affected by their toxicity to cells.[16] (3) A testing method employed to assess the toxic potential of a substance on living cells, as used to evaluate the chloroform extract of Portulaca oleracea.[17]
From: Ancient Science of Life
(1) A test to determine the toxicity of a substance to cells, often used in cancer research.[18] (2) Tests designed to determine the toxic effects of various substances on living cells, primarily to assess the safety of botanical extracts.[19]
From: International Ayurvedic Medical Journal
(1) Tests designed to evaluate the toxicity of a substance to cells, typically to determine safe dosage levels.[20]