Significance of Cytokines and chemokines
Cytokines and chemokines are signaling proteins crucial in immune responses and have significant roles across various diseases. They influence the development and severity of periodontal disease, play vital roles in the pathology of dengue infection, and mediate inflammatory responses in conditions like Rheumatoid Arthritis and liver diseases. Additionally, these proteins regulate processes such as bone remodeling during orthodontic tooth movement and respond to inflammation in diseases like COPD. Overall, cytokines and chemokines are key regulators of immune function and inflammation.
Synonyms: Cytokine, Chemokine, Signaling molecules, Immune mediators, Immune factors, Cell signaling proteins
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Cytokines and chemokines in scientific sources
Cytokines and chemokines are small proteins involved in immune cell signaling and responses. They are important in dengue pathology and play a role in recruiting leukocytes to the periodontal space, highlighting their significance in immune processes.
From: International Journal of Pharmacology
(1) Cytokines and chemokines, including chemotactic, pro-inflammatory, and antiviral types, are biologically active substances produced by virus-infected cells.[1] (2) Signaling molecules involved in immune responses and inflammation, which play a role in testicular inflammation.[2] (3) Cytokines and chemokines are involved in the pathogenesis of osteoarthritis, highlighting their role in the development of the joint disease.[3] (4) These are signaling molecules involved in immune responses, and their production can be downregulated by tetracyclines through specific signaling pathways.[4]
From: The Malaysian Journal of Medical Sciences
(1) Biological substances secreted by monocytes infected with the dengue virus that play a role in inflammation and immune response during dengue infection.[5]
From: Asian Journal of Pharmaceutics
(1) Future work will focus on profiling these produced by the macrophages in response to HL 1.[6]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) These are important mediators of immunity, and their response due to imbalance or deficiency in the cytokine network may largely determine immune disease susceptibility and severity.[7] (2) Turner, M.D. et al. discussed "cytokines and chemokines" at the crossroads of cell signalling and inflammatory disease, which indicates a focus on signaling molecules in inflammation.[8] (3) These are key participants in inflammation, working together in a protective manner to defend the body against damaging substances and various insults.[9]
From: International Journal of Pharmacology
(1) Cytokines and chemokines are signaling molecules that can increase neutrophil numbers during vascular healing and in response to cholesterol deposits.[10]