Significance of Cytochrome P450
Cytochrome P450 refers to a large family of enzymes that play an essential role in the metabolism of drugs and other substances in the body. They are involved in approximately 60% of drug oxidation reactions and can significantly impact drug-drug interactions, detoxification, and the biotransformation of various compounds. This enzyme family is crucial for how individuals respond to medications and has implications in drug metabolism and cancer. It is also involved in the metabolism of substances like alcohol and specific chemotherapeutic agents.
Synonyms: Cytochrome p450 enzyme
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The concept of Cytochrome P450 in scientific sources
Cytochrome P450 is a crucial family of enzymes that facilitate drug metabolism, detoxify xenobiotics, activate chemotherapeutic agents, metabolize substances in fungi, and play a vital role in alcohol metabolism in the liver.
From: World Journal of Pharmaceutical Research
(1) Cytochrome P450 is a family of isozymes responsible for the biotransformation of several drugs, playing a key role in drug metabolism.[1] (2) A family of enzymes involved in the metabolism of many drugs; alterations in their activity can lead to significant drug-drug interactions.[2] (3) A superfamily of enzymes involved in drug metabolism, crucial for this process and highly polymorphic across individuals.[3] (4) A large family of enzymes responsible for the metabolism of various substances within the body, including drugs.[4] (5) Cytochrome P450 refers to a family of enzymes that play a critical role in drug metabolism and can significantly affect an individual's response to medications.[5]
From: Journal of Ayurveda and Integrative Medicine
(1) A family of enzymes involved in drug metabolism and detoxification processes in the liver.[6] (2) A family of enzymes involved in drug metabolism that can be inhibited by Triphala, leading to potential drug interactions.[7]
From: The Malaysian Journal of Medical Sciences
(1) A family of phase I enzymes involved in the metabolism of approximately 60% of total drug oxidation reactions.[8]