Significance of Cumulative Dose
Cumulative Dose refers to the total amount of a drug administered to a patient over a specific period, which plays a crucial role in determining the risk of adverse effects. It is significant in various contexts like the administration of methotrexate, hydroxychloroquine, and doxorubicin, as well as the risks associated with drugs like pioglitazone and metronidazole. Understanding Cumulative Dose is essential for evaluating potential toxicity and adverse effects, thereby informing safer medication practices.
Synonyms: Total dose, Aggregate dose
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Cumulative Dose in scientific sources
Cumulative Dose encompasses the total drug quantity administered during a study, impacting toxicity assessments and adverse effects, particularly in cardiotoxicity cases, and includes specific treatment totals, like those in convalescent plasma therapy.
From: International Journal of Pharmacology
(1) The effects of these of the adrenergic agonists were investigated on the ureteral strips, both before and after blockade.[1] (2) Literature indicated that myocardial injury increases with increase in this, as observed in Sprague Dawley rats treated with the cumulative dose of 10.[2] (3) The total amount of a drug taken over time, which may influence the risk of developing statin-induced neuropathy.[3] (4) A cumulative dose refers to the total amount of a substance administered to a subject over a period of time.[4]
From: South African Family Practice
(1) This is the total dose of corticosteroids that is administered over time and can be related to side effects.[5] (2) The cumulative dose is a crucial factor in isotretinoin treatment, with a total of 120 to 150 mg/kg being required, more important than the daily dosage.[6]
From: The Malaysian Journal of Medical Sciences
(1) This is the total amount of a drug given over a period of time, which is a significant factor in the effect of a drug.[7]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) The cumulative dose of aminoglycosides has been associated with an increased risk of hearing loss, indicating that dose management is critical in preventing ototoxicity and preserving hearing function during drug-resistant tuberculosis treatment.[8] (2) The total amount of radiation delivered to the tissue over the course of treatment, influencing the overall response and potential side effects.[9] (3) The calculated dose rates can be converted to actual cumulative dose in the respiratory tracts by multiplying the dose rate by the exposure time (hours).[10] (4) The study revealed that patients with a higher cumulative dose of benzodiazepine receptor agonists were more prone to develop obstructive sleep apnea compared to those with lower doses.[11] (5) The adverse events in the late cycles were not affected by this of carfilzomib, suggesting a different mechanism for late-stage effects.[12]
From: International Journal of Pharmacology
(1) The tested compounds were administered in these at 5-minute intervals to observe dose-dependent effects.[13]