Significance of Compressibility index
The compressibility index is a key measure that reflects a powder's ability to decrease in volume under pressure, significantly influencing its flowability and compactibility during tablet formulation. This index is calculated from bulk and tapped densities, providing insight into how much a powder can be compressed. Understanding the compressibility index is essential for predicting powder behavior in manufacturing processes and ensuring the quality of final dosage forms, making it a critical parameter in pharmaceutical formulations.
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The concept of Compressibility index in scientific sources
The Compressibility index is a vital parameter that measures powder volume reduction under pressure, reflects density changes in Grevillea robusta gum, and assesses flowability and packing behavior, crucial for tablet formulation processes.
(1) A metric to assess the compressibility of granules, reflecting the relationship between bulk density and tapped density.[1] (2) The compressibility index is a measure determined by Carr’s formula, which assesses the compressibility of powders.[2] (3) A measure of the change in volume of a powder under pressure, which helps assess the flow characteristics of microspheres.[3] (4) An indication of how well a powder can flow, calculated by assessing the change in volume of the powder before and after tapping.[4] (5) A percentage value indicating the compressibility of a powder blend, assessing flow properties relevant for tablet formulation.[5]
(1) A parameter that measures the ability of a powder to decrease in volume under pressure, which is significant for the processing of powders.[6]
(1) Indicates the tendency of the powder to consolidate, reflecting the interparticulate interactions in Kushta tutia.[7]